Docetaxel Retinopathy: A Case Report

Overview

Journal Case Rep Ophthalmol

Specialty Ophthalmology

Date 2017 Feb 17

PMID 28203192

Citations 4

Authors

Sylvia Nghiem-Buffet

Salomon Yves Cohen

Audrey Giocanti-Auregan

Affiliations

Soon will be listed here.

Abstract

Background: To report the use of En-face optical coherence tomography (OCT) in a patient treated with docetaxel and tamoxifen for breast cancer for the detection of macular edema (ME) without evidence of leakage on fluorescein angiography (FA).

Case Presentation: A 52-year-old woman treated for breast cancer presented with bilateral visual loss for 2 months. FA showed no significant leakage while spectral-domain OCT scans of both eyes showed foveolar and parafoveolar cystic spaces in a moderately thickened macula. En-face OCT segmented at the inner retina showed the petaloid arrangement of cystic cavities, comparable to a cystoid ME.

Conclusions: The combined use of tamoxifen could have potentiated the toxic effect of docetaxel on the macula. En-face OCT images may reveal a petaloid aspect of the macula due to cysts in the inner retina segmentation, when FA shows no leakage.

Citing Articles

Cystoid macular oedema without leakage in fluorescein angiography: a literature review.

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Retinal Toxicity Induced by Chemical Agents.

Souza Monteiro de Araujo D, Brito R, Pereira-Figueiredo D, Dos Santos-Rodrigues A, De Logu F, Nassini R Int J Mol Sci. 2022; 23(15).

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The effect of docetaxel on retinal pigment epithelial cells.

Li J, Liu X, Yang Q, Huang J, Zhou W, Tan Z Toxicol Rep. 2022; 9:670-678.

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Docetaxel-induced maculopathy possibly potentiated by concurrent hydroxychloroquine use.

Elhusseiny A, Relhan N, Smiddy W Am J Ophthalmol Case Rep. 2019; 16:100560.

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