Stress-induced O-GlcNAcylation: an Adaptive Process of Injured Cells

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2017 Feb 17

PMID 28202678

Citations 71

Authors

Marissa R Martinez

Thiago Braido Dias

Peter S Natov

Natasha E Zachara

Affiliations

Soon will be listed here.

Abstract

In the 30 years, since the discovery of nucleocytoplasmic glycosylation, -GlcNAc has been implicated in regulating cellular processes as diverse as protein folding, localization, degradation, activity, post-translational modifications, and interactions. The cell co-ordinates these molecular events, on thousands of cellular proteins, in concert with environmental and physiological cues to fine-tune epigenetics, transcription, translation, signal transduction, cell cycle, and metabolism. The cellular stress response is no exception: diverse forms of injury result in dynamic changes to the -GlcNAc subproteome that promote survival. In this review, we discuss the biosynthesis of -GlcNAc, the mechanisms by which -GlcNAc promotes cytoprotection, and the clinical significance of these data.

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