Alpha 2-adrenoceptor-mediated Inhibition of Platelet Adenylate Cyclase Activity in Heroin Addicts in Abstinence

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1987 Jan 1

PMID 2819917

Citations 2

Authors

J A Garcia-Sevilla

I Ulibarri

L Ugedo

M Gutierrez

Affiliations

Soon will be listed here.

Abstract

The inhibition of basal and forskolin-stimulated platelet adenylate cyclase activity by (-)adrenaline was studied in ten heroin addicts during spontaneous withdrawal. Both basal and forskolin-stimulated enzyme activities were increased during heroin withdrawal and the inhibitory effect induced by (-)adrenaline was potentiated with parallel shifts to the left of the concentration-effect curves. The number of binding sites for [3H](-)adrenaline in platelet membranes was also increased during withdrawal. Treatment with clonidine markedly attenuated the inhibitory effect induced by (-)adrenaline on platelet adenylate cyclase activity. The results indicate that the heroin withdrawal syndrome induces supersensitivity of the platelet alpha 2-adrenoceptor-adenylate cyclase system.

Citing Articles

mu-Opioid receptor and alpha 2-adrenoceptor agonist binding sites in the postmortem brain of heroin addicts.

Gabilondo A, Meana J, Barturen F, Sastre M, Garcia-Sevilla J Psychopharmacology (Berl). 1994; 115(1-2):135-40.

PMID: 7862885 DOI: 10.1007/BF02244763.

Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats.

Ulibarri I, Garcia-Sevilla J, Ugedo L Naunyn Schmiedebergs Arch Pharmacol. 1987; 336(5):530-7.

PMID: 2830545 DOI: 10.1007/BF00169310.

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