Isoprenoid-phospholipid Conjugates As Potential Therapeutic Agents: Synthesis, Characterization and Antiproliferative Studies

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Feb 15

PMID 28196124

Citations 12

Authors

Anna Gliszczynska

Natalia Niezgoda

Witold Gladkowski

Marta Switalska

Joanna Wietrzyk

Affiliations

Soon will be listed here.

Abstract

The aim of this research was to extend application field of isoprenoid compounds by their introduction into phospholipid structure as the transport vehicle. The series of novel isoprenoid phospholipids were synthesized in high yields (24-97%), their structures were fully characterized and its anticancer activity was investigated in vitro towards several cell lines of different origin. Most of synthesized compounds showed a significantly higher antiproliferative effect on tested cell lines than free terpene acids. The most active phosphatidylcholine analogue, containing 2,3-dihydro-3-vinylfarnesoic acids instead of fatty acids in both sn-1 and sn-2 position, inhibits the proliferation of colon cancer cells at 13.6 μM.

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