Evolution of Gene Expression Balance Among Homeologs of Natural Polyploids

Overview

Journal G3 (Bethesda)

Publisher Oxford University Press

Specialties Genetics
Molecular Biology

Date 2017 Feb 15

PMID 28193629

Citations 14

Authors

Jasdeep S Mutti

Ramanjot K Bhullar

Kulvinder S Gill

Affiliations

Soon will be listed here.

Abstract

Polyploidy is a major evolutionary process in eukaryotes, yet the expression balance of homeologs in natural polyploids is largely unknown. To study this expression balance, the expression patterns of 2180 structurally well-characterized genes of wheat were studied, of which 813 had the expected three copies and 375 had less than three. Copy numbers of the remaining 992 ranged from 4 to 14, including homeologs, orthologs, and paralogs. Of the genes with three structural copies corresponding to homeologs, 55% expressed from all three, 38% from two, and the remaining 7% expressed from only one of the three copies. Homeologs of 76-87% of the genes showed differential expression patterns in different tissues, thus have evolved different gene expression controls, possibly resulting in novel functions. Homeologs of 55% of the genes showed tissue-specific expression, with the largest percentage (14%) in the anthers and the smallest (7%) in the pistils. The highest number (1.72/3) of homeologs/gene expression was in the roots and the lowest (1.03/3) in the anthers. As the expression of homeologs changed with changes in structural copy number, about 30% of the genes showed dosage dependence. Chromosomal location also impacted expression pattern as a significantly higher proportion of genes in the proximal regions showed expression from all three copies compared to that present in the distal regions.

Citing Articles

Homoeologs in Allopolyploids: Navigating Redundancy as Both an Evolutionary Opportunity and a Technical Challenge-A Transcriptomics Perspective.

Aufiero G, Fruggiero C, DAngelo D, DAgostino N Genes (Basel). 2024; 15(8).

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Low impact of polyploidization on the transcriptome of synthetic allohexaploid wheat.

Banouh M, Armisen D, Bouguennec A, Huneau C, Sow M, Pont C BMC Genomics. 2023; 24(1):255.

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The Shift in Synonymous Codon Usage Reveals Similar Genomic Variation during Domestication of Asian and African Rice.

Xiao G, Zhou J, Huo Z, Wu T, Li Y, Li Y Int J Mol Sci. 2022; 23(21).

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Alteration of synonymous codon usage bias accompanies polyploidization in wheat.

Tian G, Xiao G, Wu T, Zhou J, Xu W, Wang Y Front Genet. 2022; 13:979902.

PMID: 36313462 PMC: 9614214. DOI: 10.3389/fgene.2022.979902.

Expression Level Dominance and Homeolog Expression Bias Upon Cold Stress in the F1 Hybrid Between the Invasive and the Native in South China, and Implications for Its Invasiveness.

Wu W, Guo W, Ni G, Wang L, Zhang H, Ng W Front Genet. 2022; 13:833406.

PMID: 35664338 PMC: 9160872. DOI: 10.3389/fgene.2022.833406.

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