Depressive Symptoms Moderate the Relationship Between Medication Regimen Complexity and Objectively Measured Medication Adherence in Adults with Heart Failure

Overview

Journal J Behav Med

Specialty Social Sciences

Date 2017 Feb 13

PMID 28190133

Citations 5

Authors

Carly M Goldstein

Emily C Gathright

John Gunstad

Mary A Dolansky

Joseph D Redle

Richard Josephson

Shirley M Moore

Joel W Hughes

Affiliations

Soon will be listed here.

Abstract

Patients with heart failure (HF) take many medications to manage their HF and comorbidities, and 20-50% experience depression. Depressed individuals with more complex medication regimens may be at greater risk for poor adherence. The aim of this study was to assess depressive symptoms as a moderator of the relationship between medication regimen complexity and medication adherence in an observational study of patients with HF. In hierarchical linear regression with the final sample of 299, the interaction of medication regimen complexity and depressive symptoms predicted medication adherence, p < .05. For individuals with higher levels of depressive symptoms [1 standard deviation (SD) above the mean], more regimen complexity was associated with lower adherence. For individuals with low (1 SD below the mean) or average levels of depressive symptoms, regimen complexity was unrelated to medication adherence. Care management strategies, including pillboxes and caregiver involvement, may be valuable in HF patients with depression.

Citing Articles

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