Interacting Partners of FEN1 and Its Role in the Development of Anticancer Therapeutics

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Feb 11

PMID 28187440

Citations 6

Authors

Chandrasekhar Kathera

Jing Zhang

Avilala Janardhan

Hongfang Sun

Wajid Ali

Xiaolong Zhou

Lingfeng He

Zhigang Guo

Affiliations

Soon will be listed here.

Abstract

Protein-protein interaction (PPI) plays a key role in cellular communication, Protein-protein interaction connected with each other with hubs and nods involved in signaling pathways. These interactions used to develop network based biomarkers for early diagnosis of cancer. FEN1(Flap endonuclease 1) is a central component in cellular metabolism, over expression and decrease of FEN1 levels may cause cancer, these regulation changes of Flap endonuclease 1reported in many cancer cells, to consider this data may needs to develop a network based biomarker. The current review focused on types of PPI, based on nature, detection methods and its role in cancer. Interacting partners of Flap endonuclease 1 role in DNA replication repair and development of anticancer therapeutics based on Protein-protein interaction data.

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References

Cheng I, Chen B, Shuai H, Chien F, Chen P, Hsieh T . Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1. PLoS Biol. 2016; 14(1):e1002349. PMC: 4709127. DOI: 10.1371/journal.pbio.1002349. View

Choudhary C, Kumar C, Gnad F, Nielsen M, Rehman M, Walther T . Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009; 325(5942):834-40. DOI: 10.1126/science.1175371. View

Ivanov A, Khuri F, Fu H . Targeting protein-protein interactions as an anticancer strategy. Trends Pharmacol Sci. 2013; 34(7):393-400. PMC: 3773978. DOI: 10.1016/j.tips.2013.04.007. View

David S, OShea V, Kundu S . Base-excision repair of oxidative DNA damage. Nature. 2007; 447(7147):941-50. PMC: 2896554. DOI: 10.1038/nature05978. View

Henry R, Balakrishnan L, Ying-Lin S, Campbell J, Bambara R . Components of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processing. J Biol Chem. 2010; 285(37):28496-505. PMC: 2937875. DOI: 10.1074/jbc.M110.131870. View

Higurashi M, Ishida T, Kinoshita K . Identification of transient hub proteins and the possible structural basis for their multiple interactions. Protein Sci. 2007; 17(1):72-8. PMC: 2144588. DOI: 10.1110/ps.073196308. View

Guo W, Wisniewski J, Ji H . Hot spot-based design of small-molecule inhibitors for protein-protein interactions. Bioorg Med Chem Lett. 2014; 24(11):2546-54. DOI: 10.1016/j.bmcl.2014.03.095. View

Chu L, Chen B . Construction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets. BMC Syst Biol. 2008; 2:56. PMC: 2488323. DOI: 10.1186/1752-0509-2-56. View

Sun H, He L, Wu H, Pan F, Wu X, Zhao J . The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation. Oncogene. 2016; 36(2):194-207. PMC: 5140775. DOI: 10.1038/onc.2016.188. View

10.

Kidane D, Chae W, Czochor J, Eckert K, Glazer P, Bothwell A . Interplay between DNA repair and inflammation, and the link to cancer. Crit Rev Biochem Mol Biol. 2014; 49(2):116-39. PMC: 4300235. DOI: 10.3109/10409238.2013.875514. View

11.

Zhang S, Mukherjee S, Fan X, Salameh A, Mujoo K, Huang Z . Novel association of DJ-1 with HER3 potentiates HER3 activation and signaling in cancer. Oncotarget. 2016; 7(40):65758-65769. PMC: 5323190. DOI: 10.18632/oncotarget.11613. View

12.

Zheng L, Jia J, Finger L, Guo Z, Zer C, Shen B . Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res. 2010; 39(3):781-94. PMC: 3035468. DOI: 10.1093/nar/gkq884. View

13.

Hornberg J, Bruggeman F, Westerhoff H, Lankelma J . Cancer: a Systems Biology disease. Biosystems. 2006; 83(2-3):81-90. DOI: 10.1016/j.biosystems.2005.05.014. View

14.

Zhao Y, Aguilar A, Bernard D, Wang S . Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment. J Med Chem. 2014; 58(3):1038-52. PMC: 4329994. DOI: 10.1021/jm501092z. View

15.

Cusick M, Klitgord N, Vidal M, Hill D . Interactome: gateway into systems biology. Hum Mol Genet. 2005; 14 Spec No. 2:R171-81. DOI: 10.1093/hmg/ddi335. View

16.

Liu P, Qian L, Sung J, de Souza-Pinto N, Zheng L, Bogenhagen D . Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol. 2008; 28(16):4975-87. PMC: 2519700. DOI: 10.1128/MCB.00457-08. View

17.

Nikolova T, Christmann M, Kaina B . FEN1 is overexpressed in testis, lung and brain tumors. Anticancer Res. 2009; 29(7):2453-9. View

18.

Liu L, Zhou C, Zhou L, Peng L, Li D, Zhang X . Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer. Carcinogenesis. 2011; 33(1):119-23. DOI: 10.1093/carcin/bgr250. View

19.

Dorjsuren D, Kim D, Maloney D, Wilson 3rd D, Simeonov A . Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity. Nucleic Acids Res. 2010; 39(2):e11. PMC: 3025571. DOI: 10.1093/nar/gkq1082. View

20.

Varecha M, Potesilova M, Matula P, Kozubek M . Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis. Mol Cell Biochem. 2011; 363(1-2):301-7. DOI: 10.1007/s11010-011-1182-x. View