Tat is a Multifunctional Viral Protein That Modulates Cellular Gene Expression and Functions

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Feb 11

PMID 28187438

Citations 57

Authors

Evan Clark

Brenda Nava

Massimo Caputi

Affiliations

Soon will be listed here.

Abstract

The human immunodeficiency virus type I (HIV-1) has developed several strategies to condition the host environment to promote viral replication and spread. Viral proteins have evolved to perform multiple functions, aiding in the replication of the viral genome and modulating the cellular response to the infection. Tat is a small, versatile, viral protein that controls transcription of the HIV genome, regulates cellular gene expression and generates a permissive environment for viral replication by altering the immune response and facilitating viral spread to multiple tissues. Studies carried out utilizing biochemical, cellular, and genomic approaches show that the expression and activity of hundreds of genes and multiple molecular networks are modulated by Tat via multiple mechanisms.

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