Antimicrobial Use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2017 Feb 11

PMID 28185306

Citations 94

Authors

M R Lappin

J Blondeau

D Boothe

E B Breitschwerdt

L Guardabassi

D H Lloyd

M G Papich

S C Rankin

J E Sykes

J Turnidge

J S Weese

Affiliations

Soon will be listed here.

Abstract

Respiratory tract disease can be associated with primary or secondary bacterial infections in dogs and cats and is a common reason for use and potential misuse, improper use, and overuse of antimicrobials. There is a lack of comprehensive treatment guidelines such as those that are available for human medicine. Accordingly, the International Society for Companion Animal Infectious Diseases convened a Working Group of clinical microbiologists, pharmacologists, and internists to share experiences, examine scientific data, review clinical trials, and develop these guidelines to assist veterinarians in making antimicrobial treatment choices for use in the management of bacterial respiratory diseases in dogs and cats.

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References

Ruch-Gallie R, Veir J, Hawley J, Lappin M . Results of molecular diagnostic assays targeting feline herpesvirus-1 and feline calicivirus in adult cats administered modified live vaccines. J Feline Med Surg. 2011; 13(8):541-5. PMC: 10822404. DOI: 10.1016/j.jfms.2010.12.010. View

Di Martino B, Di Francesco C, Meridiani I, Marsilio F . Etiological investigation of multiple respiratory infections in cats. New Microbiol. 2007; 30(4):455-61. View

Levy J, Crawford C, Hartmann K, Hoffmann-Lehmann R, Little S, Sundahl E . 2008 Feline retrovirus management guidelines. Compend Contin Educ Vet. 2009; 31(6):E10. View

Hartmann A, Helps C, Lappin M, Werckenthin C, Hartmann K . Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections. J Vet Intern Med. 2008; 22(1):44-52. DOI: 10.1111/j.1939-1676.2007.0012.x. View

Litster A, Wu C, Constable P . Comparison of the efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in the treatment of upper respiratory tract disease in cats housed in an animal shelter. J Am Vet Med Assoc. 2012; 241(2):218-26. DOI: 10.2460/javma.241.2.218. View

Walker A, Jang S, Hirsh D . Bacteria associated with pyothorax of dogs and cats: 98 cases (1989-1998). J Am Vet Med Assoc. 2000; 216(3):359-63. DOI: 10.2460/javma.2000.216.359. View

German A, Cannon M, Dye C, Booth M, Pearson G, Reay C . Oesophageal strictures in cats associated with doxycycline therapy. J Feline Med Surg. 2005; 7(1):33-41. PMC: 10911547. DOI: 10.1016/j.jfms.2004.04.001. View

Owen W, Sturgess C, Harbour D, Egan K, Gruffydd-Jones T . Efficacy of azithromycin for the treatment of feline chlamydophilosis. J Feline Med Surg. 2003; 5(6):305-11. PMC: 10822550. DOI: 10.1016/S1098-612X(03)00072-X. View

Maggs D, Clarke H . Relative sensitivity of polymerase chain reaction assays used for detection of feline herpesvirus type 1 DNA in clinical samples and commercial vaccines. Am J Vet Res. 2005; 66(9):1550-5. DOI: 10.2460/ajvr.2005.66.1550. View

10.

Kompare B, Litster A, Leutenegger C, Weng H . Randomized masked controlled clinical trial to compare 7-day and 14-day course length of doxycycline in the treatment of Mycoplasma felis infection in shelter cats. Comp Immunol Microbiol Infect Dis. 2012; 36(2):129-35. DOI: 10.1016/j.cimid.2012.11.001. View

11.

Murphy M, Black N, Lamping D, McKEE C, Sanderson C, Askham J . Consensus development methods, and their use in clinical guideline development. Health Technol Assess. 1998; 2(3):i-iv, 1-88. View

12.

Chandler J, Lappin M . Mycoplasmal respiratory infections in small animals: 17 cases (1988-1999). J Am Anim Hosp Assoc. 2002; 38(2):111-9. DOI: 10.5326/0380111. View

13.

Johnson L, Kass P . Effect of sample collection methodology on nasal culture results in cats. J Feline Med Surg. 2009; 11(8):645-9. PMC: 11132570. DOI: 10.1016/j.jfms.2008.12.004. View

14.

Tart K, Babski D, Lee J . Potential risks, prognostic indicators, and diagnostic and treatment modalities affecting survival in dogs with presumptive aspiration pneumonia: 125 cases (2005-2008). J Vet Emerg Crit Care (San Antonio). 2010; 20(3):319-29. DOI: 10.1111/j.1476-4431.2010.00542.x. View

15.

Radhakrishnan A, Drobatz K, Culp W, King L . Community-acquired infectious pneumonia in puppies: 65 cases (1993-2002). J Am Vet Med Assoc. 2007; 230(10):1493-7. DOI: 10.2460/javma.230.10.1493. View

16.

Keil D, Fenwick B . Role of Bordetella bronchiseptica in infectious tracheobronchitis in dogs. J Am Vet Med Assoc. 1998; 212(2):200-7. View

17.

Iroh Tam P, Bernstein E, Ma X, Ferrieri P . Blood Culture in Evaluation of Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Hosp Pediatr. 2015; 5(6):324-36. DOI: 10.1542/hpeds.2014-0138. View

18.

Johnson M, Martin M . Successful medical treatment of 15 dogs with pyothorax. J Small Anim Pract. 2007; 48(1):12-6. DOI: 10.1111/j.1748-5827.2006.00235.x. View

19.

Zhu B, Johnson L, Vernau W . Tracheobronchial brush cytology and bronchoalveolar lavage in dogs and cats with chronic cough: 45 cases (2012-2014). J Vet Intern Med. 2015; 29(2):526-32. PMC: 4895494. DOI: 10.1111/jvim.12566. View

20.

Confalonieri M, Annane D, Antonaglia C, Santagiuliana M, Borriello E, Meduri G . Is prolonged low-dose glucocorticoid treatment beneficial in community-acquired pneumonia?. Curr Infect Dis Rep. 2013; 15(2):158-66. DOI: 10.1007/s11908-013-0322-8. View