Genomic Insights into a Sustained National Outbreak of Yersinia Pseudotuberculosis

Overview

Journal Genome Biol Evol

Publisher Oxford University Press

Specialties Biology
Genetics
Molecular Biology

Date 2017 Feb 8

PMID 28173076

Citations 15

Authors

Deborah A Williamson

Sarah L Baines

Glen P Carter

Anders Goncalves da Silva

Xiaoyun Ren

Jill Sherwood

Muriel Dufour

Mark B Schultz

Nigel P French

Torsten Seemann

Timothy P Stinear

Benjamin P Howden

Affiliations

Soon will be listed here.

Abstract

In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across all major cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here, we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide distribution of contaminated produce. We additionally uncovered significant diversity in key determinants of virulence, which we speculate may help explain the high morbidity linked to this outbreak.

Citing Articles

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