Pro-metastatic P53 Mutants Control Folding of N-glycoproteins

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2017 Feb 7

PMID 28166433

Citations 3

Authors

Jean Schneikert

Thorsten Stiewe

Affiliations

Soon will be listed here.

Citing Articles

: An Underexplored p53 Target Gene Linking Glycosylation and Cancer Progression.

Hu D, Kobayashi N, Ohki R Cancers (Basel). 2024; 16(15).

PMID: 39123480 PMC: 11311387. DOI: 10.3390/cancers16152753.

Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis.

Pavlakis E, Neumann M, Merle N, Wieboldt R, Wanzel M, Ponath V J Exp Clin Cancer Res. 2023; 42(1):203.

PMID: 37563605 PMC: 10413714. DOI: 10.1186/s13046-023-02785-z.

p53's Extended Reach: The Mutant p53 Secretome.

Pavlakis E, Stiewe T Biomolecules. 2020; 10(2).

PMID: 32075247 PMC: 7072272. DOI: 10.3390/biom10020307.

References

Fang M, Shen Z, Huang S, Zhao L, Chen S, Mak T . The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell. 2010; 143(5):711-24. DOI: 10.1016/j.cell.2010.10.010. View

Helenius A, Aebi M . Roles of N-linked glycans in the endoplasmic reticulum. Annu Rev Biochem. 2004; 73:1019-49. DOI: 10.1146/annurev.biochem.73.011303.073752. View

Chang J, Block T, Guo J . Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions. Antiviral Res. 2013; 99(3):251-60. PMC: 7114303. DOI: 10.1016/j.antiviral.2013.06.011. View

Schlereth K, Charles J, Bretz A, Stiewe T . Life or death: p53-induced apoptosis requires DNA binding cooperativity. Cell Cycle. 2010; 9(20):4068-76. PMC: 3055192. DOI: 10.4161/cc.9.20.13595. View

Lau K, Partridge E, Grigorian A, Silvescu C, Reinhold V, Demetriou M . Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell. 2007; 129(1):123-34. DOI: 10.1016/j.cell.2007.01.049. View