Metaphase Spindle Assembly

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2017 Feb 7

PMID 28165376

Citations 29

Authors

Tarun M Kapoor

Affiliations

Soon will be listed here.

Abstract

A microtubule-based bipolar spindle is required for error-free chromosome segregation during cell division. In this review I discuss the molecular mechanisms required for the assembly of this dynamic micrometer-scale structure in animal cells.

Citing Articles

Diverse microtubule-binding repeats regulate TPX2 activities at distinct locations within the spindle.

Liang Z, Huang J, Wang Y, Hua S, Jiang K J Cell Biol. 2025; 224(3.

PMID: 39821262 PMC: 11737348. DOI: 10.1083/jcb.202404025.

Unveiling inter-embryo variability in spindle length over time: Towards quantitative phenotype analysis.

Le Cunff Y, Chesneau L, Pastezeur S, Pinson X, Soler N, Fairbrass D PLoS Comput Biol. 2024; 20(9):e1012330.

PMID: 39236069 PMC: 11376571. DOI: 10.1371/journal.pcbi.1012330.

Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly.

Salazar B, Ohi R Mol Biol Cell. 2024; 35(6):ar84.

PMID: 38598297 PMC: 11238081. DOI: 10.1091/mbc.E24-01-0023.

The spindle protein CKAP2 regulates microtubule dynamics and ensures faithful chromosome segregation.

Paim L, Lopez-Jauregui A, McAlear T, Bechstedt S Proc Natl Acad Sci U S A. 2024; 121(9):e2318782121.

PMID: 38381793 PMC: 10907244. DOI: 10.1073/pnas.2318782121.

Sliding of antiparallel microtubules drives bipolarization of monoastral spindles.

LaFountain Jr J, Seaman C, Cohan C, Oldenbourg R Cytoskeleton (Hoboken). 2023; 81(2-3):167-183.

PMID: 37812128 PMC: 11172411. DOI: 10.1002/cm.21800.

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