Aerobic Microbiology and Culture Sensitivity of Head and Neck Space Infection of Odontogenic Origin

Overview

Journal Natl J Maxillofac Surg

Date 2017 Feb 7

PMID 28163480

Citations 10

Authors

Amit Shah

Vikas Ramola

Vijay Nautiyal

Affiliations

Soon will be listed here.

Abstract

Context: Head and neck space infections source, age, gender, tooth involved, fascial spaces involved, microbiological study of aerobic flora, and antibiotic susceptibilities.

Aims: The aim of the present study is to identify causative aerobic microorganisms responsible for deep fascial spaces of head and neck infections and evaluate the resistance of antibiotics used in the treatment of such.

Settings And Design: Prospective study in 100 patients.

Materials And Methods: This prospective study was conducted on 100 patients who reported in the outpatient department and fulfilled the inclusion criteria to study aerobic microbiology and antibiotic sensitivity in head and neck space infection of odontogenic origin. Pus sample was obtained either by aspiration or by swab stick from the involved spaces, and culture and sensitivity tests were performed.

Statistical Analysis Used: Chi-square test and level of significance.

Results: Result showed aerobic Gram-positive isolates were 73% and aerobic Gram-negative isolates were 18%. Nine percent cases showed no growth. was the highest isolate in 47% cases among Gram-positive bacteria, and in Gram-negative, was the highest isolate of total cases 11%. Amoxicillin showed resistance (48.4%) as compared to other antibiotics such as ceftriaxone, carbenicillin, amikacin, and imipenem had significantly higher sensitivity.

Conclusions: Amoxicillin with clavulanic acid showed (64.8%) efficacy for all organisms isolated, whereas ceftriaxone showed (82.4%) efficacy and could be used in odontogenic infections for both Gram-positive and Gram-negative microorganisms. Substitution of third generation cephalosporin for amoxicillin in the empirical management of deep fascial space infections can also be used. Carbenicillin, amikacin, and imipenem showed (93.4%) sensitivity against all microorganisms and should be reserved for more severe infection. Newer and broad-spectrum antibiotics are more effective than older narrow spectrum antibiotics.

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References

Rao D, Desai A, Kulkarni R, Gopalkrishnan K, Bhasker Rao C . Comparison of maxillofacial space infection in diabetic and nondiabetic patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110(4):e7-12. DOI: 10.1016/j.tripleo.2010.04.016. View

Neu H . The crisis in antibiotic resistance. Science. 1992; 257(5073):1064-73. DOI: 10.1126/science.257.5073.1064. View

Storoe W, Haug R, Lillich T . The changing face of odontogenic infections. J Oral Maxillofac Surg. 2001; 59(7):739-48; discussion 748-9. DOI: 10.1053/joms.2001.24285. View

Gorbach S, Gilmore W, Jacobus N, DOKU H, Tally F . Microbiology and antibiotic resistance in odontogenic infections. Ann Otol Rhinol Laryngol Suppl. 1991; 154:40-2. DOI: 10.1177/00034894911000s911. View

Gill Y, Scully C . Orofacial odontogenic infections: review of microbiology and current treatment. Oral Surg Oral Med Oral Pathol. 1990; 70(2):155-8. DOI: 10.1016/0030-4220(90)90109-6. View

Hunt D, Meyer R . Continued evolution of the microbiology of oral infections. J Am Dent Assoc. 1983; 107(1):52-4. DOI: 10.14219/jada.archive.1983.0191. View

Robertson D, Smith A . The microbiology of the acute dental abscess. J Med Microbiol. 2009; 58(Pt 2):155-162. DOI: 10.1099/jmm.0.003517-0. View

Rega A, Aziz S, Ziccardi V . Microbiology and antibiotic sensitivities of head and neck space infections of odontogenic origin. J Oral Maxillofac Surg. 2006; 64(9):1377-80. DOI: 10.1016/j.joms.2006.05.023. View

Brook I, Frazier E, Gher M . Aerobic and anaerobic microbiology of periapical abscess. Oral Microbiol Immunol. 1991; 6(2):123-5. DOI: 10.1111/j.1399-302x.1991.tb00464.x. View

10.

Sakaguchi M, Sato S, Ishiyama T, Katsuno S, Taguchi K . Characterization and management of deep neck infections. Int J Oral Maxillofac Surg. 1997; 26(2):131-4. DOI: 10.1016/s0901-5027(05)80835-5. View

11.

Heimdahl A, von Konow L, Nord C . Occurrence of penicillin-resistant and beta-lactamase-producing Bacteroides species in the oral cavity. Scand J Gastroenterol Suppl. 1984; 91:13-30. View

12.

Levi M, Eusterman V . Oral infections and antibiotic therapy. Otolaryngol Clin North Am. 2010; 44(1):57-78, v. DOI: 10.1016/j.otc.2010.10.003. View

13.

Kuriyama T, Nakagawa K, Karasawa T, Saiki Y, Yamamoto E, Nakamura S . Past administration of beta-lactam antibiotics and increase in the emergence of beta-lactamase-producing bacteria in patients with orofacial odontogenic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 89(2):186-92. DOI: 10.1067/moe.2000.102040. View

14.

Helstad A, KIMBALL J, Maki D . Recovery of anaerobic, facultative, and aerobic bacteria from clinical specimens in three anaerobic transport systems. J Clin Microbiol. 1977; 5(6):564-9. PMC: 274656. DOI: 10.1128/jcm.5.6.564-569.1977. View

15.

Har-El G, Aroesty J, Shaha A, Lucente F . Changing trends in deep neck abscess. A retrospective study of 110 patients. Oral Surg Oral Med Oral Pathol. 1994; 77(5):446-50. DOI: 10.1016/0030-4220(94)90221-6. View

16.

ABRAHAM E, CHAIN E . An enzyme from bacteria able to destroy penicillin. 1940. Rev Infect Dis. 1988; 10(4):677-8. View

17.

Hawkey P . Mechanisms of resistance to antibiotics. Intensive Care Med. 2000; 26 Suppl 1:S9-13. DOI: 10.1007/s001340051112. View

18.

Al-Qamachi L, Aga H, McMahon J, Leanord A, Hammersley N . Microbiology of odontogenic infections in deep neck spaces: a retrospective study. Br J Oral Maxillofac Surg. 2009; 48(1):37-9. DOI: 10.1016/j.bjoms.2008.12.007. View

19.

Poeschl P, Spusta L, Russmueller G, Seemann R, Hirschl A, Poeschl E . Antibiotic susceptibility and resistance of the odontogenic microbiological spectrum and its clinical impact on severe deep space head and neck infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110(2):151-6. DOI: 10.1016/j.tripleo.2009.12.039. View

20.

Jacoby G, Han P . Detection of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli. J Clin Microbiol. 1996; 34(4):908-11. PMC: 228915. DOI: 10.1128/jcm.34.4.908-911.1996. View