Brain Imaging Genetics in ADHD and Beyond - Mapping Pathways from Gene to Disorder at Different Levels of Complexity

Overview

Journal Neurosci Biobehav Rev

Specialties Neurology
Psychology
Social Sciences

Date 2017 Feb 5

PMID 28159610

Citations 34

Authors

Marieke Klein

Marten Onnink

Marjolein van Donkelaar

Thomas Wolfers

Benjamin Harich

Yan Shi

Janneke Dammers

Alejandro Arias-Vasquez

Martine Hoogman

Barbara Franke

Affiliations

Soon will be listed here.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common and often persistent neurodevelopmental disorder. Beyond gene-finding, neurobiological parameters, such as brain structure, connectivity, and function, have been used to link genetic variation to ADHD symptomatology. We performed a systematic review of brain imaging genetics studies involving 62 ADHD candidate genes in childhood and adult ADHD cohorts. Fifty-one eligible research articles described studies of 13 ADHD candidate genes. Almost exclusively, single genetic variants were studied, mostly focussing on dopamine-related genes. While promising results have been reported, imaging genetics studies are thus far hampered by methodological differences in study design and analysis methodology, as well as limited sample sizes. Beyond reviewing imaging genetics studies, we also discuss the need for complementary approaches at multiple levels of biological complexity and emphasize the importance of combining and integrating findings across levels for a better understanding of biological pathways from gene to disease. These may include multi-modal imaging genetics studies, bioinformatic analyses, and functional analyses of cell and animal models.

Citing Articles

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Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology.

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A Qualitative Analysis of Perspectives on Self-directed Violence in a Prospective Longitudinal Study of Young Women With and Without Childhood ADHD.

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Editorial: Modern statistical learning strategies in imaging genetics, volume II.

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The Relationship Between Emotion Dysregulation and Error Monitoring in Adolescents with ADHD.

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