Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides

Overview

Journal Nutrients

Date 2017 Feb 4

PMID 28157162

Citations 7

Authors

Jeannett Alejandra Izquierdo-Vega

Jose Antonio Morales-Gonzalez

Manuel SanchezGutierrez

Gabriel Betanzos-Cabrera

Sara M Sosa-Delgado

Maria Teresa Sumaya-Martinez

Angel Morales-Gonzalez

Rogelio Paniagua-Perez

Eduardo Madrigal-Bujaidar

Eduardo Madrigal-Santillan

Affiliations

Soon will be listed here.

Abstract

Cancer is one of the leading causes of deaths worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens or teratogens. Genotoxins are involved in the pathogenesis of several chronic degenerative diseases including hepatic, neurodegenerative and cardiovascular disorders, diabetes, arthritis, cancer, chronic inflammation and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown potential antigenotoxicity in a variety of fruits. In this review (Part 1), we present an overview of research conducted on some fruits (grapefruit, cranberries, pomegranate, guava, pineapple, and mango) which are frequentl consumed by humans, as well as the analysis of some phytochemicals extracted from fruits and yeasts which have demonstrated antigenotoxic capacity in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus and comet assay.

Citing Articles

Exploring the Antioxidant and Genoprotective Potential of Incorporation in the Diet of the European Seabass ().

Marcal R, Sousa P, Marques A, Pereira V, Guilherme S, Barreto A Animals (Basel). 2024; 14(1).

PMID: 38200822 PMC: 10778275. DOI: 10.3390/ani14010093.

Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by extract in rats: The role of γH2AX and 8-OHdG.

Yadav V, Krishnan A, Zahiruddin S, Ahmad S, Vohora D Front Pharmacol. 2023; 14:1147823.

PMID: 36969834 PMC: 10036401. DOI: 10.3389/fphar.2023.1147823.

Enzymatic Hydrolysis of Rutin: Evaluation of Kinetic Parameters and Anti-Proliferative, Mutagenic and Anti-Mutagenic Effects.

Sobreiro M, Della Torre A, de Araujo M, Canella P, de Carvalho J, de Oliveira Carvalho P Life (Basel). 2023; 13(2).

PMID: 36836907 PMC: 9967632. DOI: 10.3390/life13020549.

The Therapeutic Efficacy of and Its Bioactive Constituents with Special Reference to Photodynamic Therapy.

Fakudze N, Aniogo E, George B, Abrahamse H Plants (Basel). 2022; 11(21).

PMID: 36365273 PMC: 9654801. DOI: 10.3390/plants11212820.

Recent Studies on Berry Bioactives and Their Health-Promoting Roles.

Vahapoglu B, Erskine E, Subasi B, Capanoglu E Molecules. 2022; 27(1).

PMID: 35011338 PMC: 8747047. DOI: 10.3390/molecules27010108.

References

De Flora S, Ferguson L . Overview of mechanisms of cancer chemopreventive agents. Mutat Res. 2005; 591(1-2):8-15. DOI: 10.1016/j.mrfmmm.2005.02.029. View

Oliveira R, Pesarini J, Salles M, Nakamura Kanno T, Dos Santos Lourenco A, da Silva Leite V . Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide. Genet Mol Biol. 2014; 37(1):111-9. PMC: 3958317. DOI: 10.1590/s1415-47572014000100017. View

Alvarez-Gonzalez I, Mojica R, Madrigal-Bujaidar E, Camacho-Carranza R, Escobar-Garcia D, Espinosa-Aguirre J . The antigenotoxic effects of grapefruit juice on the damage induced by benzo(a)pyrene and evaluation of its interaction with hepatic and intestinal Cytochrome P450 (Cyp) 1a1. Food Chem Toxicol. 2010; 49(4):807-11. DOI: 10.1016/j.fct.2010.11.047. View

Perez-Sanchez A, Barrajon-Catalan E, Caturla N, Castillo J, Benavente-Garcia O, Alcaraz M . Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers. J Photochem Photobiol B. 2014; 136:12-8. DOI: 10.1016/j.jphotobiol.2014.04.007. View

Kanno S, Shouji A, Asou K, Ishikawa M . Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. J Pharmacol Sci. 2003; 92(2):166-70. DOI: 10.1254/jphs.92.166. View

Yilmaz D, Aydemir N, Vatan O, Tuzun E, Bilaloglu R . Influence of naringin on cadmium-induced genomic damage in human lymphocytes in vitro. Toxicol Ind Health. 2011; 28(2):114-21. DOI: 10.1177/0748233711407241. View

Stopper H, Schinzel R, Sebekova K, Heidland A . Genotoxicity of advanced glycation end products in mammalian cells. Cancer Lett. 2003; 190(2):151-6. DOI: 10.1016/s0304-3835(02)00626-2. View

Magnani M, Castro-Gomez R, Mori M, Kuasne H, Gregorio E, Libos Jr F . Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer. Genet Mol Biol. 2011; 34(1):131-5. PMC: 3085359. DOI: 10.1590/S1415-47572010005000103. View

Slamenova D, Kovacikova I, Horvathova E, Wsolova L, Navarova J . Carboxymethyl chitin-glucan (CM-CG) protects human HepG2 and HeLa cells against oxidative DNA lesions and stimulates DNA repair of lesions induced by alkylating agents. Toxicol In Vitro. 2010; 24(7):1986-92. DOI: 10.1016/j.tiv.2010.08.015. View

10.

Madrigal-Santillan E, Fragoso-Antonio S, Valadez-Vega C, Solano-Solano G, Perez C, Sanchez-Gutierrez M . Investigation on the protective effects of cranberry against the DNA damage induced by benzo[a]pyrene. Molecules. 2012; 17(4):4435-51. PMC: 6268607. DOI: 10.3390/molecules17044435. View

11.

Forouzanfar F, Afkhami Goli A, Asadpour E, Ghorbani A, Sadeghnia H . Protective Effect of Punica granatum L. against Serum/Glucose Deprivation-Induced PC12 Cells Injury. Evid Based Complement Alternat Med. 2013; 2013:716730. PMC: 3723082. DOI: 10.1155/2013/716730. View

12.

Philpott M, Lim C, Ferguson L . Dietary protection against free radicals: a case for multiple testing to establish structure-activity relationships for antioxidant potential of anthocyanic plant species. Int J Mol Sci. 2009; 10(3):1081-1103. PMC: 2672020. DOI: 10.3390/ijms10031081. View

13.

Del Bo C, Riso P, Campolo J, Moller P, Loft S, Klimis-Zacas D . A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutr Res. 2013; 33(3):220-7. DOI: 10.1016/j.nutres.2012.12.009. View

14.

Miyata M, Takano H, Guo L, Nagata K, Yamazoe Y . Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. Carcinogenesis. 2003; 25(2):203-9. DOI: 10.1093/carcin/bgg194. View

15.

Chorvatovicova D, Kovacikova Z, SANDULA J, Navarova J . Protective effect of sulfoethylglucan against hexavalent chromium. Mutat Res. 1993; 302(4):207-11. DOI: 10.1016/0165-7992(93)90106-6. View

16.

Wall-Medrano A, Olivas-Aguirre F, Velderrain-Rodriguez G, Gonzalez-Aguilar A, de la Rosa L, Lopez-Diaz J . [Mango: agroindustrial aspects, nutritional/functional value and health effects]. Nutr Hosp. 2015; 31(1):67-75. DOI: 10.3305/nh.2015.31.1.7701. View

17.

Ferguson L . Natural and human-made mutagens and carcinogens in the human diet. Toxicology. 2002; 181-182:79-82. DOI: 10.1016/s0300-483x(02)00258-5. View

18.

Ghavami L, Goliaei B, Taghizadeh B, Nikoofar A . Effects of barley β-glucan on radiation damage in the human hepatoma cell line HepG2. Mutat Res Genet Toxicol Environ Mutagen. 2014; 775-776:1-6. DOI: 10.1016/j.mrgentox.2014.09.005. View

19.

Matsuo T, Hanamure N, Shimoi K, Nakamura Y, Tomita I . Identification of (+)-gallocatechin as a bio-antimutagenic compound in Psidium guava leaves. Phytochemistry. 1994; 36(4):1027-9. DOI: 10.1016/s0031-9422(00)90484-9. View

20.

Rajendran P, Ekambaram G, Sakthisekaran D . Protective role of mangiferin against Benzo(a)pyrene induced lung carcinogenesis in experimental animals. Biol Pharm Bull. 2008; 31(6):1053-8. DOI: 10.1248/bpb.31.1053. View