Urine-TPA (tissue Polypeptide Antigen), Flow Cytometry and Cytology As Markers for Tumor Invasiveness in Urinary Bladder Carcinoma

Overview

Journal Urol Res

Specialty Urology

Date 1989 Jan 1

PMID 2815427

Citations 2

Authors

B E Carbin

P Ekman

P Eneroth

B Nilsson

Affiliations

Soon will be listed here.

Abstract

Urine-Tissue Polypeptide Antigen (U-TPA) was measured in 81 patients with a previously diagnosed bladder carcinoma. U-TPA was elevated in 74% of the patients with invasive bladder cancer as compared to only 15% of the patients with superficial tumors. Only one patient without a tumor recurrence had an elevated U-TPA level (4%). The results were compared with cytological grading and flow-DNA measurements in a multivariate analysis with T-category as the result variable. U-TPA and grade showed each, independently, a significant relation (P much less than 0.001) to T-category whereas the result of the DNA measurements did not explain the variation in T-category when U-TPA and grade were already in the equation. For diagnostic purposes U-TPA seems to be of limited value but may serve as an indicator of tumor recurrence in bladder cancer patients.

Citing Articles

A Systematic Review of the Diagnostic and Prognostic Value of Urinary Protein Biomarkers in Urothelial Bladder Cancer.

DCosta J, Goldsmith J, Wilson J, Bryan R, Ward D Bladder Cancer. 2016; 2(3):301-317.

PMID: 27500198 PMC: 4969711. DOI: 10.3233/BLC-160054.

Tissue polypeptide antigen and carcinoembryonic antigen lack diagnostic accuracy in urothelial carcinoma.

Stefanovic V, Mitic-Zlatkovic M, Ignjatovic I, Vlajkovic M, Scepovic Z Int Urol Nephrol. 2000; 31(4):443-9.

PMID: 10668938 DOI: 10.1023/a:1007103009313.

References

Oettgen H, Pinsky C, Schwartz M . A preliminary evaluation of tissue polypeptide antigen in serum or urine (or both) of patients with cancer or benign neoplasms. Clin Chem. 1978; 24(6):868-72. View

BJORKLUND B, Bjorklund V . Antigenicity of pooled human malignant and normal tissues by cyto-immunological technique; presence of an insoluble, heat-labile tumor antigen. Int Arch Allergy Appl Immunol. 1957; 10(3):153-84. View

Costello C, Kumar S . Prognostic value of tissue polypeptide antigen in urological neoplasia. J R Soc Med. 1985; 78(3):207-10. PMC: 1289635. DOI: 10.1177/014107688507800307. View

Gustafson H, Tribukait B, Esposti P . DNA pattern, histological grade and multiplicity related to recurrence rate in superficial bladder tumours. Scand J Urol Nephrol. 1982; 16(2):135-9. DOI: 10.3109/00365598209179742. View

Khanna O, Wu B . Tissue polypeptide antigen (TPA) as a predictor for genitourinary cancers and their metastases. Urology. 1987; 30(2):106-10. DOI: 10.1016/0090-4295(87)90172-5. View

Breslow N, Day N . Statistical methods in cancer research. Volume I - The analysis of case-control studies. IARC Sci Publ. 1980; (32):5-338. View

Kumar S, Costello C, GLASHAN R, BJORKLUND B . The clinical significance of tissue polypeptide antigen (TPA) in the urine of bladder cancer patients. Br J Urol. 1981; 53(6):578-81. DOI: 10.1111/j.1464-410x.1981.tb03264.x. View

Busch C, Engberg A, Norlen B, Stenkvist B . Malignancy grading of epithelial bladder tumours. Reproducibility of grading and comparison between forceps biopsy, aspiration biopsy and exfoliative cytology. Scand J Urol Nephrol. 1977; 11(2):143-8. DOI: 10.3109/00365597709179707. View

Carbin B, Collins V, Ekman P . Tissue polypeptide antigen (TPA), some cytokeratins and epithelial membrane antigen (EMA) in normal, inflamed and malignant urothelium. Urol Res. 1987; 15(4):191-4. DOI: 10.1007/BF00262097. View

10.

Adolphs H, Oehr P . Significance of plasma tissue polypeptide antigen determination for diagnosis and follow-up of urothelial bladder cancer. Urol Res. 1984; 12(2):125-8. DOI: 10.1007/BF00257178. View

11.

Limas C, Lange P, FRALEY E, Vessella R . A, B, H antigens in transitional cell tumors of the urinary bladder: correlation with the clinical course. Cancer. 1979; 44(6):2099-107. DOI: 10.1002/1097-0142(197912)44:6<2099::aid-cncr2820440621>3.0.co;2-i. View

12.

Tribukait B, Gustafson H, Esposti P . Ploidy and proliferation in human bladder tumors as measured by flow-cytofluorometric DNA-analysis and its relations to histopathology and cytology. Cancer. 1979; 43(5):1742-51. DOI: 10.1002/1097-0142(197905)43:5<1742::aid-cncr2820430525>3.0.co;2-c. View

13.

Esposti P, MOBERGER G, Zajicek J . The cytologic diagnosis of transitional cell tumors of the urinary bladder and its histologic basis. A study of 567 cases of urinary-tract disorder including 170 untreated and 182 irradiated bladder tumors. Acta Cytol. 1970; 14(3):145-55. View