Promoter Polymorphism (-590, T/C) of Interleukin 4 () Gene is Associated with Rheumatoid Arthritis: An Updated Meta-analysis

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2017 Feb 3

PMID 28149185

Citations 10

Authors

Hyun Kyung Park

Su Kang Kim

Hae Yong Kweon

Kwan Gill Lee

Mariadhas Valan Arasu

Young Ock Kim

Affiliations

Soon will be listed here.

Abstract

Rheumatoid arthritis (RA) is a chronic disease. It causes chronic inflammation of the joint. Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA). Especially, it was reported that promoter polymorphism (-590, T/C) of gene has been associated with susceptibility of RA. The aim of present study was to investigate whether the promoter polymorphism (-590, T/C) of gene is associated with the susceptibility of RA using meta-analysis. And in order to perform meta-analysis, comprehensive meta analysis program was used. Genetic models (co-dominant, dominant, recessive, and allele) were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and values. Nine case-control studies with case and control design were included in this meta-analysis. Overall, meta-analysis revealed a strong association with susceptibility of RA [OR = 1.303, 95% CI = 1.093-1.554, = 0.003 in allele model (C vs. T); OR = 1.247, 95% CI = 1.054-1.474, = 0.010 in dominant model (CC vs. CT + TT); OR = 2.148, 95% CI = 1.263-3.651, = 0.005 in recessive model (CC + CT vs. TT)]. Our data demonstrated that promoter polymorphism (-590, T/C) of gene may be contributed to susceptibility of RA. However, more studies with a larger sample size are needed to provide more precise evidence.

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