Supplement of Levosimendan to Epinephrine Improves Initial Resuscitation Outcomes from Asphyxial Cardiac Arrest

Overview

Journal BMC Anesthesiol

Publisher Biomed Central

Specialty Anesthesiology

Date 2017 Feb 3

PMID 28148233

Citations 3

Authors

Bingjing Wu

Yong G Peng

Shishi Zhao

Nana Bao

Linmin Pan

Jiaojiao Dong

Xuzhong Xu

Quanguang Wang

Affiliations

Soon will be listed here.

Abstract

Background: Levosimendan exerted favorable effects on the initial outcome in the treatment of ventricular fibrillation cardiac arrest. This study investigated the efficacy of levosimendan in the treatment of asphyxia-induced cardiac arrest in rats.

Methods: Animals underwent asphyxial cardiac arrest/cardiopulmonary resuscitation, randomized to three treatment groups: epinephrine (10 μg/kg) supplemented with levosimendan (bolus 12 μg/kg and infusion for 1 h, EL group); epinephrine only (10 μg/kg, E group), or levosimendan only (bolus 12 μg/kg and infusion for 1 h, L group). The resuscitation success rate, wet-to-dry ratio of lung, and rate of alveolar and blood gas analysis were recorded.

Results: 10 rats in the EL group, 8 in the E group, and 2 in the L group showed an initial return of spontaneous circulation (P < 0.001); among them, 10, 4, and 2 rats survived at the end of a 60-min observation period from each group, respectively (P = 0.001). The coronary perfusion pressure in the EL group was higher than that of either the E or L group (P < 0.05). The lung wet-to-dry weight ratio and rate of damaged alveoli were lower in the EL group than the E group (P < 0.05).

Conclusions: In the early stage of resuscitation for asphyxia-induced cardiac arrest in rats, levosimendan supplemented with epinephrine can significantly increase coronary perfusion pressure, reduce lung injury, and ultimately enhance the survival rate.

Citing Articles

Rat model of asphyxia-induced cardiac arrest and resuscitation.

Yu S, Wu C, Zhu Y, Diao M, Hu W Front Neurosci. 2023; 16:1087725.

PMID: 36685224 PMC: 9846144. DOI: 10.3389/fnins.2022.1087725.

Levosimendan increases brain tissue oxygen levels after cardiopulmonary resuscitation independent of cardiac function and cerebral perfusion.

Garcia-Bardon A, Kamuf J, Ziebart A, Liu T, Krebs N, Dunges B Sci Rep. 2021; 11(1):14220.

PMID: 34244561 PMC: 8270955. DOI: 10.1038/s41598-021-93621-x.

Levosimendan combined with epinephrine improves rescue outcomes in a rat model of lipid-based resuscitation from bupivacaine-induced cardiac arrest.

Nan F, Cai X, Ye Y, Xu X, Li Z, Li M BMC Anesthesiol. 2017; 17(1):128.

PMID: 28915792 PMC: 5602843. DOI: 10.1186/s12871-017-0414-3.

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