Tissue-specific Differentiation of Colonic Macrophages Requires TGFβ Receptor-mediated Signaling

Overview

Journal Mucosal Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2017 Feb 2

PMID 28145440

Citations 85

Authors

A Schridde

C C Bain

J U Mayer

J Montgomery

E Pollet

B Denecke

S W F Milling

S J Jenkins

M Dalod

S Henri

B Malissen

O Pabst

A Mcl Mowat

Affiliations

Soon will be listed here.

Abstract

Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6C monocytes, but the factors driving this tissue-specific process are not understood. Here we have used global transcriptomic analysis to identify a unique homeostatic signature of mature colonic mφ that is acquired as they differentiate in the mucosa. By comparing the analogous monocyte differentiation process found in the dermis, we identify TGFβ as an indispensable part of monocyte differentiation in the intestine and show that it enables mφ to adapt precisely to the requirements of their environment. Importantly, TGFβR signaling on mφ has a crucial role in regulating the accumulation of monocytes in the mucosa, via mechanisms that are distinct from those used by IL10.

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