Skin: A Mirror of Internal Malignancy

Overview

Journal Indian J Med Paediatr Oncol

Publisher Thieme

Specialty Oncology

Date 2017 Feb 2

PMID 28144085

Citations 5

Authors

Rita V Vora

Rahulkrishna S Kota

Nilofar G Diwan

Nidhi B Jivani

Shailee S Gandhi

Affiliations

Soon will be listed here.

Abstract

Skin manifestations are a reflection of many of the internal diseases. Sometimes, skin disease may be the only manifestation of the internal disease. Internal malignancies may give rise to a number of cutaneous manifestations through their immunological, metabolic, and metastatic consequences. Curth proposed criteria to establish a causal relationship between a dermatosis and a malignant internal disease. Malignancy can present with a plethora of cutaneous manifestations. Here, we describe in brief about various skin manifestations of internal malignancies.

Citing Articles

Unveiling the Unseen: A Rare Case of Primary Pulmonary Lymphoma.

Jose M, Jayanthi N, P H, P S Cureus. 2024; 16(10):e70959.

PMID: 39507165 PMC: 11540108. DOI: 10.7759/cureus.70959.

CAN SKIN BE A MARKER FOR INTERNAL MALIGNANCY? EVIDENCE FROM CLINICAL CASES.

Lugovic-Mihic L, Kristo M, Spoljar S, Novak-Bilic G, Beslic I, Vucic M Acta Clin Croat. 2022; 60(4):711-721.

PMID: 35734490 PMC: 9196211. DOI: 10.20471/acc.2021.60.04.19.

Malignant acanthosis nigricans as a paraneoplastic manifestation of metastatic breast cancer.

Arellano J, Iglesias P, Suarez C, Corredoira Y, Schnettler K Int J Womens Dermatol. 2019; 5(3):183-186.

PMID: 31360756 PMC: 6637086. DOI: 10.1016/j.ijwd.2019.03.002.

Obligate and facultative paraneoplastic dermatoses: an overview.

Caccavale S, Brancaccio G, Agozzino M, Vitiello P, Alfano R, Argenziano G Dermatol Pract Concept. 2018; 8(3):191-197.

PMID: 30116663 PMC: 6092071. DOI: 10.5826/dpc.0803a09.

Erythromelalgia: a cutaneous manifestation of neuropathy?.

Leroux M An Bras Dermatol. 2018; 93(1):86-94.

PMID: 29641704 PMC: 5871369. DOI: 10.1590/abd1806-4841.20187535.

References

Bitar G, Herman C, Dahman M, Hoard M . Basal cell nevus syndrome: guidelines for early detection. Am Fam Physician. 2002; 65(12):2501-4. View

Cohen P . Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy-associated mucocutaneous paraneoplastic syndromes. Int J Dermatol. 2006; 45(1):70-80. DOI: 10.1111/j.1365-4632.2005.02667.x. View

Dozois R, Judd E, Dahlin D, Bartholomew L . The Peutz-Jeghers syndrome. Is there a predisposition to the development of intestinal malignancy?. Arch Surg. 1969; 98(4):509-17. DOI: 10.1001/archsurg.1969.01340100125017. View

Helm T, Camisa C, Liu A, Valenzuela R, Bergfeld W . Lichen planus associated with neoplasia: a cell-mediated immune response to tumor antigens?. J Am Acad Dermatol. 1994; 30(2 Pt 1):219-24. DOI: 10.1016/s0190-9622(94)70020-6. View

Grob J, Rava M, Gouvernet J, Fuentes P, Piana L, Gamerre M . The relation between seborrheic keratoses and malignant solid tumours. A case-control study. Acta Derm Venereol. 1991; 71(2):166-9. View

Bolognia J, Brewer Y, Cooper D . Bazex syndrome (acrokeratosis paraneoplastica). An analytic review. Medicine (Baltimore). 1991; 70(4):269-80. DOI: 10.1097/00005792-199107000-00004. View

Grob J, Horchowski N, Dufaud M, Prin L, Bonerandi J . Ofuji papuloerythroderma. Report of a case with T cell skin lymphoma and discussion of the nature of this disease. J Am Acad Dermatol. 1989; 20(5 Pt 2):927-31. View

Salem O, STECK W . Cowden's disease (multiple hamartoma and neoplasia syndrome). A case report and review of the English literature. J Am Acad Dermatol. 1983; 8(5):686-96. DOI: 10.1016/s0190-9622(83)70081-2. View

Burt R, Sharfman W, Karp B, Wilson W . Mental neuropathy (numb chin syndrome). A harbinger of tumor progression or relapse. Cancer. 1992; 70(4):877-81. DOI: 10.1002/1097-0142(19920815)70:4<877::aid-cncr2820700425>3.0.co;2-g. View

10.

REINGOLD I . Cutaneous metastases from internal carcinoma. Cancer. 1966; 19(2):162-8. DOI: 10.1002/1097-0142(196602)19:2<162::aid-cncr2820190204>3.0.co;2-a. View

11.

Benedek T . Paraneoplastic digital clubbing and hypertrophic osteoarthropathy. Clin Dermatol. 1993; 11(1):53-9. DOI: 10.1016/0738-081x(93)90082-n. View

12.

Nair P, Nanda K, Jayapalan S . The "sign of groove", a new cutaneous sign of internal malignancy. Indian J Dermatol Venereol Leprol. 2007; 73(2):141. DOI: 10.4103/0378-6323.31911. View

13.

Tyring S . Reactive erythemas: erythema annulare centrifugum and erythema gyratum repens. Clin Dermatol. 1993; 11(1):135-9. DOI: 10.1016/0738-081x(93)90110-x. View

14.

Rosen T . Cutaneous metastases. Med Clin North Am. 1980; 64(5):885-900. DOI: 10.1016/s0025-7125(16)31572-3. View

15.

Boyce S, Harper J . Paraneoplastic dermatoses. Dermatol Clin. 2002; 20(3):523-32. DOI: 10.1016/s0733-8635(02)00015-3. View

16.

Lookingbill D, Spangler N, Helm K . Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol. 1993; 29(2 Pt 1):228-36. DOI: 10.1016/0190-9622(93)70173-q. View

17.

Hill C, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A . Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet. 2001; 357(9250):96-100. DOI: 10.1016/S0140-6736(00)03540-6. View

18.

Schwartz R . Acanthosis nigricans. J Am Acad Dermatol. 1994; 31(1):1-19; quiz 20-2. DOI: 10.1016/s0190-9622(94)70128-8. View

19.

Adreev V, Petkov I . Skin manifestations associated with tumours of the brain. Br J Dermatol. 1975; 92(6):675-678. DOI: 10.1111/j.1365-2133.1975.tb03148.x. View

20.

Pipkin C, A Lio P . Cutaneous manifestations of internal malignancies: an overview. Dermatol Clin. 2007; 26(1):1-15, vii. DOI: 10.1016/j.det.2007.08.002. View