Systemic Activation of Toll-like Receptor 2 Suppresses Mitochondrial Respiration and Exacerbates Hypoxic-ischemic Injury in the Developing Brain

Overview

Journal J Cereb Blood Flow Metab

Publisher Sage Publications

Specialties Cardiology & Vascular Diseases
Endocrinology
Neurology

Date 2017 Feb 1

PMID 28139935

Citations 22

Authors

Amin Mottahedin

Pernilla Svedin

Syam Nair

Carl-Johan Mohn

Xiaoyang Wang

Henrik Hagberg

Joakim Ek

Carina Mallard

Affiliations

Soon will be listed here.

Abstract

Infection and inflammation are known risk factors for neonatal brain injury. Mycoplasma and Gram-positive bacteria, for which Toll-like receptor 2 (TLR2) plays a key role in recognition and inflammatory response, are among the most common pathogens in the perinatal period. Here, we report that systemic activation of TLR2 by Pam3CSK4 (P3C) increases neural tissue loss and demyelination induced by subsequent hypoxia-ischemia (HI) in neonatal mice. High-resolution respirometry of brain isolated mitochondria revealed that P3C suppresses ADP-induced oxidative phosphorylation, the main pathway of cellular energy production. The results suggest that infection and inflammation might contribute to HI-induced energy failure.

Citing Articles

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