Peripheral Vein Infusions of Amino Acids Facilitate Recovery After Esophagectomy for Esophageal Cancer: Retrospective Cohort Analysis

Overview

Journal Ann Med Surg (Lond)

Publisher Wolters Kluwer

Specialty Medical Education

Date 2017 Feb 1

PMID 28138387

Authors

Masafumi Konosu

Takeshi Iwaya

Yusuke Kimura

Yuji Akiyama

Yoshihiro Shioi

Fumitaka Endo

Hiroyuki Nitta

Koki Otsuka

Keisuke Koeda

Akira Sasaki

Affiliations

Soon will be listed here.

Abstract

Background: To investigate the efficacy of amino acid administration via peripheral veins in addition to conventional enteral feeding following esophagectomy.

Materials And Methods: Retrospective analysis of data pertaining to 33 patients with esophageal cancer who underwent radical esophagectomy and satisfied the required nutrition control. Patients were divided into the amino acid group (n = 17) and control group (n = 16). Primary outcomes were albumin (Alb) and prealbumin (PreAlb) levels, urinary 3-methylhistidine/creatinine (3-MeHis/Cre) ratios, nitrogen balance, and weight; postoperative complications were noted as secondary outcomes.

Results: Alb levels were significantly higher in the amino acid group on postoperative day (POD)-14 (3.4 ± 0.3 vs. 3.1 ± 0.4 mg/dL in the control group, = 0.018) and at 1 month after surgery (3.8 ± 0.4 vs. 3.5 ± 0.3 mg/dL, = 0.045). No significant differences were observed in PreAlb and urinary 3-MeHis/Cre rates between the treatment groups. Body weights at 3 months postoperatively were decreased by 6% and 3% in the control and amino acid groups, respectively.

Conclusion: Peripheral venous administration of amino acids soon after surgical stress is an effective method for nutritional control.

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