Serum Levels of Undercarboxylated Osteocalcin Are Related to Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus and Healthy Subjects

Overview

Journal World J Diabetes

Publisher Baishideng Publishing Group

Specialty Endocrinology

Date 2017 Feb 1

PMID 28138360

Citations 18

Authors

Sergio Sanchez-Enriquez

Isabel Thalia Ballesteros-Gonzalez

Jose Rafael Villafan-Bernal

Sara Pascoe-Gonzalez

Edgar Alfonso Rivera-Leon

Blanca Estela Bastidas-Ramirez

Jorge David Rivas-Carrillo

Juan Luis Alcala-Zermeno

Juan Armendariz-Borunda

Iris Monserrat Llamas-Covarrubias

Abraham Zepeda-Moreno

Affiliations

Soon will be listed here.

Abstract

Aim: To determine a potential relationship between serum undercarboxylated (ucOC) concentration and cardiovascular risk factors in type 2 diabetes (T2D) patients and healthy subjects (HS).

Methods: A cross-sectional study was conducted on 140 subjects classified into two groups, 70 with T2D and 70 HS. Medical history and physical examination with anthropometric measurements were obtained from all subjects. Body fat percentage was determined by bioelectrical impendency analysis. Serum ucOC concentration was determined by enzyme immunoassay, while serum levels of insulin and hsCRP were obtained using high sensitivity enzyme-linked immunosorbent assay. Insulin resistance was determined using the homeostasis model assessment-IR. Lipid profile [triglycerides, total cholesterol (TC), high-density lipoproteins (HDL-c), low density lipoproteins (LDL-c), very low-density lipoproteins] was determined by spectrophotometry and standard formulas when applicable.

Results: The T2D patient group showed significantly higher values of waist circumference, waist-to-hip ratio, systolic blood pressure (SBP), diastolic blood pressure (DBP), current smoking, and alcohol use when compared to the HS group ( < 0.05). We observed a significantly lower serum ucOC concentration in T2D than in HS (1.5 ± 1.4 2.3 ± 1.8, < 0.05). In the whole study population, ucOC concentration was inversely correlated with body mass index (BMI) ( = -0.236, < 0.05), fasting plasma glucose ( = -0.283, < 0.01) and HDL-c ( = -0.255, < 0.05); and positively correlated with LDL-c/HDL-c ratio ( = 0.306, < 0.05) and TC/HDL-c ratio ( = 0.284, < 0.05). In the T2D group, serum ucOC concentration was inversely correlated with BMI ( = -0.310, < 0.05) and body-fat percentage ( = -0.311, < 0.05), and positively correlated with DBP ( = 0.450, < 0.01). In HS group a positive correlation between serum levels of ucOC and SBP ( = 0.277, < 0.05) was observed.

Conclusion: Serum ucOC is a potential marker for cardiovascular risk in Mexicans because it is related to adiposity parameters, blood pressure and lipid profile.

Citing Articles

Carboxylated Osteocalcin as an Independent Predictor of Mean Arterial Pressure and the Atherogenic Index in Adults.

Villafan-Bernal J, Rivas-Carrillo J, Guzman-Guzman I, Frias-Cabrera J, Rivera-Leon E, Martinez-Portilla R Int J Mol Sci. 2025; 26(4).

PMID: 40004196 PMC: 11855918. DOI: 10.3390/ijms26041733.

Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases.

Martiniakova M, Biro R, Kovacova V, Babikova M, Zemanova N, Mondockova V J Mol Med (Berl). 2024; 102(4):435-452.

PMID: 38363329 PMC: 10963459. DOI: 10.1007/s00109-024-02418-8.

Osteocalcin and Metabolic Syndrome.

Viswanath A, Vidyasagar S, Sukumar C Clin Med Insights Endocrinol Diabetes. 2023; 16:11795514231206729.

PMID: 37954481 PMC: 10634259. DOI: 10.1177/11795514231206729.

Osteocalcin serum concentrations and markers of energetic metabolism in pediatric patients. Systematic review and metanalysis.

Rodriguez-Narciso S, Martinez-Portilla R, Guzman-Guzman I, Careaga-Cardenas G, Rubio-Navarro B, Barba-Gallardo L Front Pediatr. 2023; 10:1075738.

PMID: 36714656 PMC: 9878130. DOI: 10.3389/fped.2022.1075738.

Increased Advanced Glycation Endproducts, Stiffness, and Hardness in Iliac Crest Bone From Postmenopausal Women With Type 2 Diabetes Mellitus on Insulin.

Lekkala S, Sacher S, Taylor E, Williams R, Moseley K, Donnelly E J Bone Miner Res. 2022; 38(2):261-277.

PMID: 36478472 PMC: 9898222. DOI: 10.1002/jbmr.4757.

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