Genetic and Epigenetic Control of the Spatial Organization of the Genome

Overview

Journal Mol Biol Cell

Specialties Cell Biology
Molecular Biology

Date 2017 Feb 1

PMID 28137949

Citations 12

Authors

Jason Brickner

Affiliations

Soon will be listed here.

Abstract

Eukaryotic genomes are spatially organized within the nucleus by chromosome folding, interchromosomal contacts, and interaction with nuclear structures. This spatial organization is observed in diverse organisms and both reflects and contributes to gene expression and differentiation. This leads to the notion that the arrangement of the genome within the nucleus has been shaped and conserved through evolutionary processes and likely plays an adaptive function. Both DNA-binding proteins and changes in chromatin structure influence the positioning of genes and larger domains within the nucleus. This suggests that the spatial organization of the genome can be genetically encoded by binding sites for DNA-binding proteins and can also involve changes in chromatin structure, potentially through nongenetic mechanisms. Here I briefly discuss the results that support these ideas and their implications for how genomes encode spatial organization.

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