Dietary Fatty Acid Metabolism of Brown Adipose Tissue in Cold-acclimated Men

Overview

Journal Nat Commun

Specialty Biology

Date 2017 Jan 31

PMID 28134339

Citations 67

Authors

Denis P Blondin

Hans C Tingelstad

Christophe Noll

Frederique Frisch

Serge Phoenix

Brigitte Guerin

Eric E Turcotte

Denis Richard

Francois Haman

Andre C Carpentier

Affiliations

Soon will be listed here.

Abstract

In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue in non-cold-acclimated men given a standard liquid meal containing the long-chain fatty acid PET tracer, 14(R,S)-[F]-fluoro-6-thia-heptadecanoic acid (FTHA). However, the net contribution of BAT to systemic DFA clearance is comparatively small. Despite a 4-week cold acclimation increasing BAT oxidative metabolism 2.6-fold, BAT DFA uptake does not increase further. These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues.

Citing Articles

New improved radiometabolite analysis method for [F]FTHA from human plasma: a test-retest study with postprandial and fasting state.

Aarnio R, Kirjavainen A, Rajander J, Forsback S, Kalliokoski K, Nuutila P EJNMMI Res. 2024; 14(1):53.

PMID: 38869780 PMC: 11176130. DOI: 10.1186/s13550-024-01114-5.

Cold exposure increases circulating fibroblast growth factor 21 in the evening in males and females.

Hoekx C, Martinez-Tellez B, Straat M, Verkleij M, Kemmeren M, Kooijman S Endocr Connect. 2024; 13(7).

PMID: 38781402 PMC: 11227058. DOI: 10.1530/EC-24-0074.

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation.

Jia D, Zhang H, Liu T, Wang R Metabolites. 2024; 14(3).

PMID: 38535295 PMC: 10972279. DOI: 10.3390/metabo14030135.

Highland deer mice support increased thermogenesis in response to chronic cold hypoxia by shifting uptake of circulating fatty acids from muscles to brown adipose tissue.

Lyons S, McClelland G J Exp Biol. 2024; 227(7).

PMID: 38506250 PMC: 11057874. DOI: 10.1242/jeb.247340.

Brown adipose tissue metabolism in women is dependent on ovarian status.

Blondin D, Haman F, Swibas T, Hogan-Lamarre S, Dumont L, Guertin J Am J Physiol Endocrinol Metab. 2024; 326(5):E588-E601.

PMID: 38477875 PMC: 11211003. DOI: 10.1152/ajpendo.00077.2024.

References

van der Lans A, Hoeks J, Brans B, Vijgen G, Visser M, Vosselman M . Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest. 2013; 123(8):3395-403. PMC: 3726172. DOI: 10.1172/JCI68993. View

Bartelt A, Bruns O, Reimer R, Hohenberg H, Ittrich H, Peldschus K . Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011; 17(2):200-5. DOI: 10.1038/nm.2297. View

Hanssen M, van der Lans A, Brans B, Hoeks J, Jardon K, Schaart G . Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans. Diabetes. 2016; 65(5):1179-89. DOI: 10.2337/db15-1372. View

Haman F, Legault S, Weber J . Fuel selection during intense shivering in humans: EMG pattern reflects carbohydrate oxidation. J Physiol. 2004; 556(Pt 1):305-13. PMC: 1664890. DOI: 10.1113/jphysiol.2003.055152. View

St-Onge M, Mignault D, Allison D, Rabasa-Lhoret R . Evaluation of a portable device to measure daily energy expenditure in free-living adults. Am J Clin Nutr. 2007; 85(3):742-9. DOI: 10.1093/ajcn/85.3.742. View

Brown M, Marshall D, Sobel B, Bergmann S . Delineation of myocardial oxygen utilization with carbon-11-labeled acetate. Circulation. 1987; 76(3):687-96. DOI: 10.1161/01.cir.76.3.687. View

Labbe S, Grenier-Larouche T, Croteau E, Normand-Lauziere F, Frisch F, Ouellet R . Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography. Am J Physiol Endocrinol Metab. 2010; 300(3):E445-53. DOI: 10.1152/ajpendo.00579.2010. View

Ci X, Frisch F, Lavoie F, Germain P, Lecomte R, van Lier J . The effect of insulin on the intracellular distribution of 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid in rats. Mol Imaging Biol. 2006; 8(4):237-44. DOI: 10.1007/s11307-006-0042-7. View

McEneny J, McMaster C, Trimble E, Young I . Rapid isolation of VLDL subfractions: assessment of composition and susceptibility to copper-mediated oxidation. J Lipid Res. 2002; 43(5):824-31. View

10.

McEneny J, Trimble E, Young I . A simple method for assessing copper-mediated oxidation of very-low-density lipoprotein isolated by rapid ultracentrifugation. Ann Clin Biochem. 1998; 35 ( Pt 4):504-14. DOI: 10.1177/000456329803500404. View

11.

PATLAK C, Blasberg R, Fenstermacher J . Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 1983; 3(1):1-7. DOI: 10.1038/jcbfm.1983.1. View

12.

Kim J, Wang Z, Heymsfield S, Baumgartner R, Gallagher D . Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method. Am J Clin Nutr. 2002; 76(2):378-83. DOI: 10.1093/ajcn/76.2.378. View

13.

Sallis J, Haskell W, Wood P, Fortmann S, Rogers T, Blair S . Physical activity assessment methodology in the Five-City Project. Am J Epidemiol. 1985; 121(1):91-106. DOI: 10.1093/oxfordjournals.aje.a113987. View

14.

Tchoukalova Y, Koutsari C, Karpyak M, Votruba S, Wendland E, Jensen M . Subcutaneous adipocyte size and body fat distribution. Am J Clin Nutr. 2008; 87(1):56-63. DOI: 10.1093/ajcn/87.1.56. View

15.

Rothwell N, Stock M . A role for brown adipose tissue in diet-induced thermogenesis. Nature. 1979; 281(5726):31-5. DOI: 10.1038/281031a0. View

16.

Ouellet V, Labbe S, Blondin D, Phoenix S, Guerin B, Haman F . Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest. 2012; 122(2):545-52. PMC: 3266793. DOI: 10.1172/JCI60433. View

17.

Lee P, Smith S, Linderman J, Courville A, Brychta R, Dieckmann W . Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes. 2014; 63(11):3686-98. PMC: 4207391. DOI: 10.2337/db14-0513. View

18.

Laplante M, Festuccia W, Soucy G, Blanchard P, Renaud A, Berger J . Tissue-specific postprandial clearance is the major determinant of PPARgamma-induced triglyceride lowering in the rat. Am J Physiol Regul Integr Comp Physiol. 2008; 296(1):R57-66. DOI: 10.1152/ajpregu.90552.2008. View

19.

Kunach M, Noll C, Phoenix S, Guerin B, Baillargeon J, Turcotte E . Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans. Diabetes. 2014; 64(7):2432-41. DOI: 10.2337/db14-1166. View

20.

Carpentier A, Patterson B, Uffelman K, Giacca A, Vranic M, Cattral M . The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism. Diabetes. 2001; 50(6):1402-13. DOI: 10.2337/diabetes.50.6.1402. View