Evolution of B Cell Analysis and Env Trimer Redesign

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2017 Jan 31

PMID 28133805

Citations 19

Authors

Gunilla B Karlsson Hedestam

Javier Guenaga

Martin Corcoran

Richard T Wyatt

Affiliations

Soon will be listed here.

Abstract

HIV-1 and its surface envelope glycoproteins (Env), gp120 and gp41, have evolved immune evasion strategies that render the elicitation of effective antibody responses to the functional Env entry unit extremely difficult. HIV-1 establishes chronic infection and stimulates vigorous immune responses in the human host; forcing selection of viral variants that escape cellular and antibody (Ab)-mediated immune pressure, yet possess contemporary fitness. Successful survival of fit variants through the gauntlet of the human immune system make this virus and these glycoproteins a formidable challenge to target by vaccination, requiring a systematic approach to Env mimetic immunogen design and evaluation of elicited responses. Here, we review key aspects of HIV-1 Env immunogenicity and immunogen re-design, based on experimental data generated by us and others over the past decade or more. We further provide rationale and details regarding the use of newly evolving tools to analyze B cell responses, including approaches to use next generation sequencing for antibody lineage tracing and B cell fate mapping. Together, these developments offer opportunities to address long-standing questions about the establishment of effective B cell immunity elicited by vaccination, not just against HIV-1.

Citing Articles

RAIN: machine learning-based identification for HIV-1 bNAbs.

Foglierini M, Nortier P, Schelling R, Winiger R, Jacquet P, ODell S Nat Commun. 2024; 15(1):5339.

PMID: 38914562 PMC: 11196741. DOI: 10.1038/s41467-024-49676-1.

RAIN: a Machine Learning-based identification for HIV-1 bNAbs.

Perez L, Foglierini M Res Sq. 2024; .

PMID: 38903123 PMC: 11188109. DOI: 10.21203/rs.3.rs-4023897/v1.

Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response.

Bale S, Yang L, Alirezaei M, Wilson R, Ota T, Doyle E Front Immunol. 2023; 14:1180959.

PMID: 37283743 PMC: 10239957. DOI: 10.3389/fimmu.2023.1180959.

Addressing IGHV Gene Structural Diversity Enhances Immunoglobulin Repertoire Analysis: Lessons From Rhesus Macaque.

Kaduk M, Corcoran M, Karlsson Hedestam G Front Immunol. 2022; 13:818440.

PMID: 35419009 PMC: 8995469. DOI: 10.3389/fimmu.2022.818440.

Aljedani S, Liban T, Tran K, Phad G, Singh S, Dubrovskaya V PLoS Pathog. 2021; 17(9):e1009543.

PMID: 34559844 PMC: 8494329. DOI: 10.1371/journal.ppat.1009543.

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