Administration of an Activin Receptor IIB Ligand Trap Protects Male Juvenile Rhesus Macaques from Simian Immunodeficiency Virus-associated Bone Loss

Overview

Journal Bone

Specialties Endocrinology
Orthopedics

Date 2017 Jan 31

PMID 28132908

Citations 6

Authors

Wen Guo

Karol M Pencina

Karyn OConnell

Monty Montano

Liming Peng

Susan Westmoreland

Julie Glowacki

Shalender Bhasin

Affiliations

Soon will be listed here.

Abstract

Conclusion: The administration of ActRIIB.FC in SIV-infected juvenile macaques significantly increases BMC and BMD in association with reduced expression levels of markers of bone marrow inflammation.

Citing Articles

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Functional replacement of myostatin with GDF-11 in the germline of mice.

Lee S, Lehar A, Rydzik R, Youngstrom D, Bhasin S, Liu Y Skelet Muscle. 2022; 12(1):7.

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Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs.

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Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy.

Long K, OShea K, Khairallah R, Howell K, Paushkin S, Chen K Hum Mol Genet. 2018; 28(7):1076-1089.

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Effects of an ActRIIB.Fc Ligand Trap on Cardiac Function in Simian Immunodeficiency Virus-Infected Male Rhesus Macaques.

Guo W, Pencina K, Gagliano-Juca T, Jasuja R, Morris N, OConnell K J Endocr Soc. 2018; 2(8):817-831.

PMID: 30019021 PMC: 6041778. DOI: 10.1210/js.2018-00099.

References

Mantzoros C, Flier J, Rogol A . A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab. 1997; 82(4):1066-70. DOI: 10.1210/jcem.82.4.3878. View

Liu W, Thomas S, Asa S, Gonzalez-Cadavid N, Bhasin S, Ezzat S . Myostatin is a skeletal muscle target of growth hormone anabolic action. J Clin Endocrinol Metab. 2003; 88(11):5490-6. DOI: 10.1210/jc.2003-030497. View

Kooij K, Wit F, Bisschop P, Schouten J, Stolte I, Prins M . Low bone mineral density in patients with well-suppressed HIV infection: association with body weight, smoking, and prior advanced HIV disease. J Infect Dis. 2014; 211(4):539-48. DOI: 10.1093/infdis/jiu499. View

Frost H . Muscle, bone, and the Utah paradigm: a 1999 overview. Med Sci Sports Exerc. 2000; 32(5):911-7. DOI: 10.1097/00005768-200005000-00006. View

Chisada S, Okamoto H, Taniguchi Y, Kimori Y, Toyoda A, Sakaki Y . Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and hypertrophy, which occur sequentially during post-hatch development. Dev Biol. 2011; 359(1):82-94. DOI: 10.1016/j.ydbio.2011.08.027. View

Hamrick M, Arounleut P, Kellum E, Cain M, Immel D, Liang L . Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury. J Trauma. 2010; 69(3):579-83. PMC: 3738012. DOI: 10.1097/TA.0b013e3181c451f4. View

Townson S, Martinez-Hackert E, Greppi C, Lowden P, Sako D, Liu J . Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex. J Biol Chem. 2012; 287(33):27313-25. PMC: 3431715. DOI: 10.1074/jbc.M112.377960. View

Borderi M, Gibellini D, Vescini F, De Crignis E, Cimatti L, Biagetti C . Metabolic bone disease in HIV infection. AIDS. 2009; 23(11):1297-310. DOI: 10.1097/QAD.0b013e32832ce85a. View

Zhou X, Wang J, Lu J, Song Y, Kwak K, Jiao Q . Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell. 2010; 142(4):531-43. DOI: 10.1016/j.cell.2010.07.011. View

10.

Yong M, Elliott J, Woolley I, Hoy J . Low CD4 count is associated with an increased risk of fragility fracture in HIV-infected patients. J Acquir Immune Defic Syndr. 2011; 57(3):205-10. DOI: 10.1097/QAI.0b013e31821ecf4c. View

11.

Baron R, Rawadi G . Wnt signaling and the regulation of bone mass. Curr Osteoporos Rep. 2007; 5(2):73-80. DOI: 10.1007/s11914-007-0006-0. View

12.

Hamrick M, McPherron A, Lovejoy C, Hudson J . Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice. Bone. 2000; 27(3):343-9. DOI: 10.1016/s8756-3282(00)00339-2. View

13.

Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C . Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med. 2015; 21(9):1085-90. DOI: 10.1038/nm.3917. View

14.

Kambadur R, Sharma M, Smith T, Bass J . Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res. 1997; 7(9):910-6. DOI: 10.1101/gr.7.9.910. View

15.

Invernizzi M, Carda S, Rizzi M, Grana E, Squarzanti D, Cisari C . Evaluation of serum myostatin and sclerostin levels in chronic spinal cord injured patients. Spinal Cord. 2015; 53(8):615-20. DOI: 10.1038/sc.2015.61. View

16.

Shuto T, Sarkar G, Bronk J, Matsui N, Bolander M . Osteoblasts express types I and II activin receptors during early intramembranous and endochondral bone formation. J Bone Miner Res. 1997; 12(3):403-11. DOI: 10.1359/jbmr.1997.12.3.403. View

17.

Bowser M, Herberg S, Arounleut P, Shi X, Fulzele S, Hill W . Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Exp Gerontol. 2012; 48(2):290-7. PMC: 3678732. DOI: 10.1016/j.exger.2012.11.004. View

18.

Baek K, Hwang H, Park H, Kwon A, Qadir A, Ko S . TNF-α upregulates sclerostin expression in obese mice fed a high-fat diet. J Cell Physiol. 2014; 229(5):640-50. DOI: 10.1002/jcp.24487. View

19.

Teichmann J, Lange U, Discher T, Lohmeyer J, Stracke H, Bretzel R . Bone mineral density in human immunodeficiency virus-1 infected men with hypogonadism prior to highly-active-antiretroviral-therapy (HAART). Eur J Med Res. 2009; 14:59-64. PMC: 3351961. DOI: 10.1186/2047-783x-14-2-59. View

20.

Freeman L, Mansfield K, Lackner A, Naumova E, Gorbach S . Survival and failure to thrive in the SIV-infected juvenile rhesus monkey. J Acquir Immune Defic Syndr. 2000; 22(2):119-23. DOI: 10.1097/00126334-199910010-00002. View