» Articles » PMID: 28130788

Increased Risk of Mortality by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-analysis

Abstract

Conclusion: The risk of liver-related mortality increases exponentially with increase in fibrosis stage; these data have important implications in assessing the utility of each stage and benefits of regression of fibrosis from one stage to another. (Hepatology 2017;65:1557-1565).

Citing Articles

The effect of SGLT2 inhibitors on hepatic steatosis detected by MRI-PDFF in patients with type 2 Diabetes mellitus and metabolic-associated steatotic liver disease.

Amin M, Sadik N, Saad H, Fawzy M, Elsheimy H Intern Emerg Med. 2025; .

PMID: 40085410 DOI: 10.1007/s11739-025-03902-w.


The association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and liver fibrosis in US adults.

Liu W, Li X, Chen L, Luo X BMC Endocr Disord. 2025; 25(1):67.

PMID: 40065306 PMC: 11895387. DOI: 10.1186/s12902-025-01891-7.


Advanced Liver Fibrosis Impairs Cardiorespiratory Fitness in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.

Sogbe M, Hummer B, Stine J, Lizaola-Mayo B, Forman D, Vargas H Dig Dis Sci. 2025; .

PMID: 39966289 DOI: 10.1007/s10620-025-08893-4.


Resmetirom: Breakthrough therapeutic approach for metabolic dysfunction-associated steatohepatitis.

Saeed A, Rai K, Saeed M Liver Res. 2025; 8(3):193-194.

PMID: 39957747 PMC: 11771249. DOI: 10.1016/j.livres.2024.07.002.


Impact of steatotic liver disease subtypes, sarcopenia, and fibrosis on all-cause and cause-specific mortality: a 15.7-year cohort study.

Liang Y, Ye X, Pan M, Chen Y, Yuan Y, Luo L BMC Gastroenterol. 2025; 25(1):75.

PMID: 39934679 PMC: 11818238. DOI: 10.1186/s12876-025-03661-0.


References
1.
Leung J, Loong T, Wei J, Wong G, Chan A, Choi P . Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients. Hepatology. 2016; 65(1):54-64. DOI: 10.1002/hep.28697. View

2.
Stepanova M, de Avila L, Afendy M, Younossi I, Pham H, Cable R . Direct and Indirect Economic Burden of Chronic Liver Disease in the United States. Clin Gastroenterol Hepatol. 2016; 15(5):759-766.e5. DOI: 10.1016/j.cgh.2016.07.020. View

3.
Bertolotti M, Lonardo A, Mussi C, Baldelli E, Pellegrini E, Ballestri S . Nonalcoholic fatty liver disease and aging: epidemiology to management. World J Gastroenterol. 2014; 20(39):14185-204. PMC: 4202348. DOI: 10.3748/wjg.v20.i39.14185. View

4.
Goossens N, Hoshida Y, Song W, Jung M, Morel P, Nakagawa S . Nonalcoholic Steatohepatitis Is Associated With Increased Mortality in Obese Patients Undergoing Bariatric Surgery. Clin Gastroenterol Hepatol. 2015; 14(11):1619-1628. PMC: 4838546. DOI: 10.1016/j.cgh.2015.10.010. View

5.
Targher G, Byrne C, Lonardo A, Zoppini G, Barbui C . Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis. J Hepatol. 2016; 65(3):589-600. DOI: 10.1016/j.jhep.2016.05.013. View