Sequence-Selective Binding of Oligopeptides in Water Through Hydrophobic Coding

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2017 Jan 28

PMID 28128940

Citations 30

Authors

Joseph K Awino

Roshan W Gunasekara

Yan Zhao

Affiliations

Soon will be listed here.

Abstract

A general method for sequence-specific binding of peptides remains elusive despite decades of research. By creating an array of "hydrophobically coded dimples" on the surface of surface-core doubly cross-linked micelles, we synthesized water-soluble nanoparticle receptors to recognize peptides by the location, number, and nature of their hydrophobic side chains. Minute differences in the side chains could be distinguished, and affinities up to 20 nM were obtained for biologically active oligopeptides in water.

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