MiR-222 in Cardiovascular Diseases: Physiology and Pathology

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2017 Jan 28

PMID 28127557

Citations 37

Authors

Shengguang Ding

Haitao Huang

Yiming Xu

Hao Zhu

Chongjun Zhong

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs and miRs) are endogenous 19-22 nucleotide, small noncoding RNAs with highly conservative and tissue specific expression. They can negatively modulate target gene expressions through decreasing transcription or posttranscriptional inducing mRNA decay. Increasing evidence suggests that deregulated miRNAs play an important role in the genesis of cardiovascular diseases. Additionally, circulating miRNAs can be biomarkers for cardiovascular diseases. MiR-222 has been reported to play important roles in a variety of physiological and pathological processes in the heart. Here we reviewed the recent studies about the roles of miR-222 in cardiovascular diseases. MiR-222 may be a potential cardiovascular biomarker and a new therapeutic target in cardiovascular diseases.

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References

Jansen F, Yang X, Proebsting S, Hoelscher M, Przybilla D, Baumann K . MicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease. J Am Heart Assoc. 2014; 3(6):e001249. PMC: 4338711. DOI: 10.1161/JAHA.114.001249. View

Riedel S, Radzanowski S, Bowen T, Werner S, Erbs S, Schuler G . Exercise training improves high-density lipoprotein-mediated transcription of proangiogenic microRNA in endothelial cells. Eur J Prev Cardiol. 2014; 22(7):899-903. DOI: 10.1177/2047487314541036. View

Tanasescu M, Leitzmann M, Rimm E, Willett W, Stampfer M, Hu F . Exercise type and intensity in relation to coronary heart disease in men. JAMA. 2002; 288(16):1994-2000. DOI: 10.1001/jama.288.16.1994. View

Su M, Chen Z, Wang C, Song L, Zou Y, Zhang L . Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice. Cell Physiol Biochem. 2016; 39(4):1503-11. DOI: 10.1159/000447853. View

Duan M, Yao H, Hu G, Chen X, Lund A, Buch S . HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy. PLoS One. 2013; 8(3):e60170. PMC: 3610892. DOI: 10.1371/journal.pone.0060170. View

Zhang C, Zhang J, Zhang A, Wang Y, Han L, You Y . PUMA is a novel target of miR-221/222 in human epithelial cancers. Int J Oncol. 2010; 37(6):1621-6. DOI: 10.3892/ijo_00000816. View

Moran A, Gu D, Zhao D, Coxson P, Wang Y, Chen C . Future cardiovascular disease in china: markov model and risk factor scenario projections from the coronary heart disease policy model-china. Circ Cardiovasc Qual Outcomes. 2010; 3(3):243-52. PMC: 2937540. DOI: 10.1161/CIRCOUTCOMES.109.910711. View

Bernardo B, Gao X, Winbanks C, Boey E, Tham Y, Kiriazis H . Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proc Natl Acad Sci U S A. 2012; 109(43):17615-20. PMC: 3491509. DOI: 10.1073/pnas.1206432109. View

Li D, Ji L, Liu L, Liu Y, Hou H, Yu K . Characterization of circulating microRNA expression in patients with a ventricular septal defect. PLoS One. 2014; 9(8):e106318. PMC: 4148428. DOI: 10.1371/journal.pone.0106318. View

10.

Van Rooij E, Sutherland L, Liu N, Williams A, McAnally J, Gerard R . A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A. 2006; 103(48):18255-60. PMC: 1838739. DOI: 10.1073/pnas.0608791103. View

11.

Fu X, Wang Q, Chen J, Huang X, Chen X, Cao L . Clinical significance of miR-221 and its inverse correlation with p27Kip¹ in hepatocellular carcinoma. Mol Biol Rep. 2010; 38(5):3029-35. DOI: 10.1007/s11033-010-9969-5. View

12.

Visone R, Russo L, Pallante P, De Martino I, Ferraro A, Leone V . MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocr Relat Cancer. 2007; 14(3):791-8. DOI: 10.1677/ERC-07-0129. View

13.

Bergmann O, Bhardwaj R, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S . Evidence for cardiomyocyte renewal in humans. Science. 2009; 324(5923):98-102. PMC: 2991140. DOI: 10.1126/science.1164680. View

14.

Abel E, Doenst T . Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy. Cardiovasc Res. 2011; 90(2):234-42. PMC: 3115280. DOI: 10.1093/cvr/cvr015. View

15.

Tao L, Bei Y, Zhang H, Xiao J, Li X . Exercise for the heart: signaling pathways. Oncotarget. 2015; 6(25):20773-84. PMC: 4673228. DOI: 10.18632/oncotarget.4770. View

16.

Volinia S, Calin G, Liu C, Ambs S, Cimmino A, Petrocca F . A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A. 2006; 103(7):2257-61. PMC: 1413718. DOI: 10.1073/pnas.0510565103. View

17.

Miller T, Ghoshal K, Ramaswamy B, Roy S, Datta J, Shapiro C . MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. J Biol Chem. 2008; 283(44):29897-903. PMC: 2573063. DOI: 10.1074/jbc.M804612200. View

18.

Liu X, Cheng Y, Zhang S, Lin Y, Yang J, Zhang C . A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res. 2009; 104(4):476-87. PMC: 2728290. DOI: 10.1161/CIRCRESAHA.108.185363. View

19.

Bazan H, Hatfield S, OMalley C, Brooks A, Lightell Jr D, Woods T . Acute Loss of miR-221 and miR-222 in the Atherosclerotic Plaque Shoulder Accompanies Plaque Rupture. Stroke. 2015; 46(11):3285-7. PMC: 4624519. DOI: 10.1161/STROKEAHA.115.010567. View

20.

Starr J . Tetralogy of fallot: yesterday and today. World J Surg. 2010; 34(4):658-68. DOI: 10.1007/s00268-009-0296-8. View