Interactions Between Kisspeptin Neurons and Hypothalamic Tuberoinfundibular Dopaminergic Neurons in Aged Female Rats

Overview

Journal Acta Histochem Cytochem

Specialty Biochemistry

Date 2017 Jan 28

PMID 28127107

Citations 2

Authors

Kinuyo Iwata

Masaaki Ikehara

Yuyu Kunimura

Hitoshi Ozawa

Affiliations

Soon will be listed here.

Abstract

Kisspeptin neurons in the arcuate nucleus (ARC) regulate prolactin secretion, and are in physical contact with tuberoinfundibular dopaminergic (TIDA) neurons, which inhibit prolactin secretion. Prolactin levels in the blood are increased with advancing age in rats; therefore, we investigated the interactions with TIDA neurons and kisspeptin neurons in aged female rats (24 months of age), relative to those of young adult female rats (9-10 weeks of age). Plasma prolactin levels in the aged rats were significantly higher than those of young adult rats. Tyrosine hydroxylase (TH)-immunoreactive (ir) cell bodies and kisspeptin-ir nerve fibers were found in the dorsomedial ARC of both groups. The number of TH-ir cell bodies in the dorsomedial ARC did not differ significantly between groups. Additionally, no significant differences in the number of TH-ir cells in contact with kisspeptin-ir fibers was observed between groups. However, the number of kisspeptin-ir or mRNA-expressing cells in the ARC was significantly reduced in the aged rats compared with that of the young rats. These results suggest that the contacts between TIDA neurons and kisspeptin neurons are maintained after reproductive senescence, while production of kisspeptin in the ARC decreases significantly during aging.

Citing Articles

Hypothalamic Kisspeptin Expression in Hyperandrogenic Female Rats and Aging Rats.

Iwata K, Kunimura Y, Ozawa H Acta Histochem Cytochem. 2019; 52(5):85-91.

PMID: 31777408 PMC: 6872488. DOI: 10.1267/ahc.19013.

Prolactin Biology and Laboratory Measurement: An Update on Physiology and Current Analytical Issues.

Saleem M, Martin H, Coates P Clin Biochem Rev. 2018; 39(1):3-16.

PMID: 30072818 PMC: 6069739.

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