A Simplified and Scalable Synthesis of Artesunate

Overview

Journal Monatsh Chem

Specialty Chemistry

Date 2017 Jan 28

PMID 28127092

Citations 8

Authors

Armin Presser

Andrea Feichtinger

Silke Buzzi

Affiliations

Soon will be listed here.

Abstract

Abstract: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH-induced reduction, followed by an esterification with succinic anhydride under basic conditions. The entire conversion follows the principles of green chemistry, i.e., application of reusable solvents.

Graphical Abstract:

Citing Articles

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