Comparison of Serotype Prevalence of Pneumococci Isolated from Middle Ear, Lower Respiratory Tract and Invasive Disease Prior to Vaccination in Iceland

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Jan 27

PMID 28125588

Citations 3

Authors

Martha A Hjalmarsdottir

Sigridur Julia Quirk

Gunnsteinn Haraldsson

Helga Erlendsdottir

Asgeir Haraldsson

Karl G Kristinsson

Affiliations

Soon will be listed here.

Abstract

Background: Information on pneumococcal serotype distribution before vaccination is a prerequisite for evaluation of vaccine effect. The aim was to investigate the prevalence of pneumococcal serotypes isolated from middle ear (ME), lower respiratory tract (LRT) and from invasive disease (IPD) in Iceland prior to implementation of ten-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV-10) into the infant vaccination program (April 2011).

Methods And Findings: All isolates cultured 2007-2011 from ME, LRT and IPD identified as pneumococci were serotyped and tested for susceptibility at the Clinical Microbiology Department, Landspitali University Hospital that serves approximately 85% of the Icelandic population. Pneumococcal isolates were 1711 and 1616 (94.4%) were available for serotyping and included. Isolates belonging to PHiD-CV10 serotypes (VTs) were 1052 (65.1%). Isolates from ME were 879 (54.4%), with 639 (72.7%) from 0-1 year old patients and 651 of VTs (74%). Isolates from LRT were 564 (34.9%), with 292 (51.8%) from ≥65 years old patients, and 300 (53.2%) of VTs. IPD isolates were 173 (10.7%), although more evenly distributed according to age than isolates from the other sites most were from adults and the youngest age group,101 (58.4%) isolates were of VTs. The most common serotype was 19F, 583 (36.1%). Its prevalence was highest in ME, 400 (45.5%), 172 (30.5%) in LRT and 11 isolates (6.4%), in IPD. Penicillin non-susceptible isolates were 651 (40.3%), mainly belonging to VTs, 611 (93.9%), including 535 (82.2%) of 19F.

Conclusions: Multiresistant isolates of serotype 19F were highly prevalent, especially from ME of young children but also from LRT of adults. Serotype 14 was the most common serotype in IPD. The rate of VTs was high and almost all PNSP were of VTs. There was great difference in vaccine coverage between sampling sites, also reflecting difference in vaccine coverage by age groups.

Citing Articles

Epidemiology of non-vaccine serotypes of before and after universal administration of pneumococcal conjugate vaccines.

Du Q, Shi W, Yu D, Yao K Hum Vaccin Immunother. 2021; 17(12):5628-5637.

PMID: 34726580 PMC: 8903918. DOI: 10.1080/21645515.2021.1985353.

Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland.

Hjalmarsdottir M, Haraldsson G, Quirk S, Haraldsson A, Erlendsdottir H, Kristinsson K PLoS One. 2020; 15(3):e0230332.

PMID: 32182260 PMC: 7077842. DOI: 10.1371/journal.pone.0230332.

Vaccination of Icelandic Children with the 10-Valent Pneumococcal Vaccine Leads to a Significant Herd Effect among Adults in Iceland.

Quirk S, Haraldsson G, Hjalmarsdottir M, van Tonder A, Hrafnkelsson B, Bentley S J Clin Microbiol. 2019; 57(4).

PMID: 30651396 PMC: 6440763. DOI: 10.1128/JCM.01766-18.

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