Association of in Utero Magnesium Exposure and Spontaneous Intestinal Perforations in Extremely Low Birth Weight Infants

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2017 Jan 27

PMID 28125094

Citations 7

Authors

L C Downey

C M Cotten

C P Hornik

M M Laughon

V N Tolia

R H Clark

P B Smith

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study is to determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation (SIP) in extremely low birth weight (ELBW) infants (⩽1000 g).

Study Design: We identified all ELBW infants admitted to 1 of 323 neonatal intensive care units from 2007 to 2013. We used multivariable conditional logistic regression to compare outcomes in the first 21 days after birth between infants exposed and unexposed to magnesium in utero.

Results: Of the 28 035 infants, 11 789 (42%) were exposed to antenatal magnesium (AM). There was no difference in the risk of SIP, odds ratio=1.08 (95% confidence interval; 0.91 to 1.29), between infants exposed and unexposed to AM. Mortality in the first 21 days after birth was lower in the magnesium-exposed infants, odds ratio=0.76 (0.70 to 0.83).

Conclusion: AM exposure in ELBW infants was not associated with increased risk of SIP.

Citing Articles

Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22-24 weeks' gestational age.

Thakkar P, Sutton K, Detwiler C, Henegar J, Narayan J, Perez-Romero M J Perinatol. 2023; 44(1):94-99.

PMID: 37759034 PMC: 11465378. DOI: 10.1038/s41372-023-01782-6.

Antenatal Magnesium Sulfate and adverse gastrointestinal outcomes in Preterm infants-a systematic review and meta-analysis.

Prasath A, Aronoff N, Chandrasekharan P, Diggikar S J Perinatol. 2023; 43(9):1087-1100.

PMID: 37391507 DOI: 10.1038/s41372-023-01710-8.

Antenatal Steroids, Prophylactic Indomethacin, and the Risk of Spontaneous Intestinal Perforation.

Laptook A, Weydig H, Brion L, Wyckoff M, Arnautovic T, Younge N J Pediatr. 2023; 259:113457.

PMID: 37172814 PMC: 10524442. DOI: 10.1016/j.jpeds.2023.113457.

Increased Risk of Meconium-Related Ileus in Extremely Premature Infants Exposed to Antenatal Magnesium Sulfate.

Sung S, Ahn S, Choi S, Oh S, Roh C, Yang M Neonatology. 2022; 119(1):68-76.

PMID: 35016173 PMC: 8984996. DOI: 10.1159/000520452.

Antenatal magnesium sulfate treatment and risk of necrotizing enterocolitis in preterm infants born at less than 32 weeks of gestation.

Hong J, Hong J, Choi Y, Kim Y, Sung J, Choi S Sci Rep. 2020; 10(1):12826.

PMID: 32733081 PMC: 7393352. DOI: 10.1038/s41598-020-69785-3.

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