Noisy Spiking in Visual Area V2 of Amblyopic Monkeys

Overview

Journal J Neurosci

Specialty Neurology

Date 2017 Jan 27

PMID 28123026

Citations 17

Authors

Ye Wang

Bin Zhang

Xiaofeng Tao

Janice M Wensveen

Earl L Smith Rd

Yuzo M Chino

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Amblyopia is a common developmental vision disorder in humans. Despite the extensive animal studies on how amblyopia emerges, we know surprisingly little about the neural basis of amblyopia in humans and nonhuman primates. Although the vision of amblyopic humans is often described as being noisy by perceptual and modeling studies, the exact nature or origin of this elevated perceptual noise is not known. We show that elevated and noisy spontaneous activity and contrast-dependent noisy spiking (spiking irregularity and trial-to-trial fluctuations in spiking) in neurons of visual area V2 could limit the visual performance of amblyopic primates. Moreover, we discovered that the noisy spiking is linked to a high level of binocular suppression in visual cortex during development.

Citing Articles

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Contour integration deficits at high spatial frequencies in children treated for anisometropic amblyopia.

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Amblyopia and the whole child.

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Rethinking amblyopia 2020.

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