Proteome Changes of Human Bone Marrow Mesenchymal Stem Cells Induced by 1,4-Benzoquinone

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2017 Jan 26

PMID 28119923

Citations 5

Authors

Wei Wu

Ling Zhang

Min Zhang

Li-Jin Zhu

Hai-Ling Xia

Jian-Lin Lou

Jia-Ren Liu

Yun Xiao

Affiliations

Soon will be listed here.

Abstract

Benzene is metabolized to hydroquinone in liver and subsequently transported to bone marrow for further oxidization to 1,4-benzoquinone (1,4-BQ), which may be related to the leukemia and other blood disorders. In the present study, we investigated the proteome profiles of human primary bone marrow mesenchymal stem cells (hBM-MSCs) treated by 1,4-BQ. We identified 32 proteins that were differentially expressed. Two of them, HSP27 and Vimentin, were verified at both mRNA and protein levels and their cellular localization was examined by immunofluorescence. We also found increased mRNA level of RAP1GDS1, a critical factor of metabolism that has been identified as a fusion partner in various hematopoietic malignancies. Therefore, these differentially expressed proteins can play important roles in benzene-mediated hematoxicity.

Citing Articles

A systematic review and meta-analysis comparing robotic-assisted percutaneous screw fixation and conventional surgical techniques for acetabular fractures.

Zhu H, Li D, Li Y, Xu W, Chen G J Robot Surg. 2024; 19(1):17.

PMID: 39623136 DOI: 10.1007/s11701-024-02177-1.

The pressing need for study on the effects of Mpox on the progression of vascular inflammation: A well-timed call.

Meem S, Proma A, Bhuiyan M, Dewan S Health Sci Rep. 2024; 7(7):e2223.

PMID: 38946778 PMC: 11211998. DOI: 10.1002/hsr2.2223.

Clinical results of acetabular fracture treatment with hybrid fixation by anterior and posterior approach : A minimally invasive technique.

Qoreishy M, Sajedi A, Gholipour M, Gorji M, Maleki A Wien Klin Wochenschr. 2023; 136(19-20):556-561.

PMID: 37815673 DOI: 10.1007/s00508-023-02277-2.

The Impact of Sedentary Lifestyle, High-fat Diet, Tobacco Smoke, and Alcohol Intake on the Hematopoietic Stem Cell Niches.

Kaastrup K, Gronbaek K Hemasphere. 2021; 5(8):e615.

PMID: 34291194 PMC: 8288907. DOI: 10.1097/HS9.0000000000000615.

Ju L, Wu W, Yin X, Xiao Y, Jia Z, Lou J FEBS Open Bio. 2017; 7(10):1469-1479.

PMID: 28979837 PMC: 5623706. DOI: 10.1002/2211-5463.12274.

References

Nies E, Korinth G . Commentary on "Penetration of benzene, toluene and xylenes contained in gasolines through human abdominal skin in vitro". Toxicol In Vitro. 2007; 22(1):275-7. DOI: 10.1016/j.tiv.2007.04.015. View

Ock S, Jeon B, Rho G . Comparative characterization of porcine mesenchymal stem cells derived from bone marrow extract and skin tissues. Tissue Eng Part C Methods. 2010; 16(6):1481-91. DOI: 10.1089/ten.TEC.2010.0149. View

Rappaport S, Waidyanatha S, Qu Q, Shore R, Jin X, Cohen B . Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism. Cancer Res. 2002; 62(5):1330-7. View

Kalf G, Hazel B, Hoffmann M, Kim D, Snyder R . The interaction of 1,4-benzoquinone, a bioreactive intermediate of benzene, with three proteins essential for differentiation/maturation of the mouse myeloid stem cell. Adv Exp Med Biol. 2002; 500:429-39. DOI: 10.1007/978-1-4615-0667-6_65. View

Mansi A, Bruni R, Capone P, Paci E, Pigini D, Simeoni C . Low occupational exposure to benzene in a petrochemical plant: modulating effect of genetic polymorphisms and smoking habit on the urinary t,t-MA/SPMA ratio. Toxicol Lett. 2011; 213(1):57-62. DOI: 10.1016/j.toxlet.2011.02.001. View

Abernethy D, Kleymenova E, Rose J, Recio L, Faiola B . Human CD34+ hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone. Toxicol Sci. 2004; 79(1):82-9. DOI: 10.1093/toxsci/kfh095. View

Westphal G, Bunger J, Lichey N, Taeger D, Monnich A, Hallier E . The benzene metabolite para-benzoquinone is genotoxic in human, phorbol-12-acetate-13-myristate induced, peripheral blood mononuclear cells at low concentrations. Arch Toxicol. 2009; 83(7):721-9. PMC: 3085764. DOI: 10.1007/s00204-009-0402-6. View

Dong H, Zhang S, Sun W, Liu Q, Ibla J, Soriano S . β-Ionone arrests cell cycle of gastric carcinoma cancer cells by a MAPK pathway. Arch Toxicol. 2013; 87(10):1797-808. DOI: 10.1007/s00204-013-1041-5. View

Lee D, Ahn Y, Kim S, Wang K, Cho B, Phi J . Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin Cancer Res. 2009; 15(15):4925-34. DOI: 10.1158/1078-0432.CCR-08-3076. View

10.

Li Y, Sun W, Liu H, Qi G, Wang Q, Sun X . γ-Tocotrienol inhibits angiogenesis of human umbilical vein endothelial cell induced by cancer cell. J Nutr Biochem. 2011; 22(12):1127-36. DOI: 10.1016/j.jnutbio.2010.09.012. View

11.

Liu Q, Dong H, Sun W, Liu M, Ibla J, Liu L . Apoptosis initiation of β-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway. Arch Toxicol. 2012; 87(3):481-90. DOI: 10.1007/s00204-012-0962-8. View

12.

Faiola B, Fuller E, Wong V, Pluta L, Abernethy D, Rose J . Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression. Stem Cells. 2004; 22(5):750-8. DOI: 10.1634/stemcells.22-5-750. View

13.

Yoon B, Hirabayashi Y, Kawasaki Y, Kodama Y, Kaneko T, Kim D . Mechanism of action of benzene toxicity: cell cycle suppression in hemopoietic progenitor cells (CFU-GM). Exp Hematol. 2001; 29(3):278-85. DOI: 10.1016/s0301-472x(00)00671-8. View

14.

Xiao Y, Ju L, Wu W, Gao X, Wang J, Zhang X . [Effects of 1,4-benzoquinone on the proliferation activity of human bone marrow stem cells]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012; 30(5):343-7. View

15.

Stastna M, Behrens A, McDonnell P, Van Eyk J . Analysis of protein composition of rabbit aqueous humor following two different cataract surgery incision procedures using 2-DE and LC-MS/MS. Proteome Sci. 2011; 9(1):8. PMC: 3045281. DOI: 10.1186/1477-5956-9-8. View

16.

Xie Z, Zhang Y, Guliaev A, Shen H, Hang B, Singer B . The p-benzoquinone DNA adducts derived from benzene are highly mutagenic. DNA Repair (Amst). 2005; 4(12):1399-409. DOI: 10.1016/j.dnarep.2005.08.012. View

17.

Liu J, Chen B, Yang B, Dong H, Sun C, Wang Q . Apoptosis of human gastric adenocarcinoma cells induced by beta-ionone. World J Gastroenterol. 2004; 10(3):348-51. PMC: 4724910. DOI: 10.3748/wjg.v10.i3.348. View

18.

Tunsaringkarn T, Siriwong W, Rungsiyothin A, Nopparatbundit S . Occupational exposure of gasoline station workers to BTEX compounds in Bangkok, Thailand. Int J Occup Environ Med. 2012; 3(3):117-25. View

19.

Mendez-Ferrer S, Michurina T, Ferraro F, Mazloom A, MacArthur B, Lira S . Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010; 466(7308):829-34. PMC: 3146551. DOI: 10.1038/nature09262. View

20.

Ma Y, Xu Y, Xiao Z, Yang W, Zhang C, Song E . Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells. Stem Cells. 2005; 24(2):315-21. DOI: 10.1634/stemcells.2005-0046. View