Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus

Overview

Journal Front Genet

Date 2017 Jan 26

PMID 28119736

Citations 16

Authors

Zane A Goodwin

Cristina de Guzman Strong

Affiliations

Soon will be listed here.

Abstract

The epidermal differentiation complex (EDC) is the most rapidly evolving locus in the human genome compared to that of the chimpanzee. Yet the EDC genes that are undergoing positive selection across mammals and in humans are not known. We sought to identify the positively selected genetic variants and determine the evolutionary events of the EDC using mammalian-wide and clade-specific branch- and branch-site likelihood ratio tests and a genetic algorithm (GA) branch test. Significant non-synonymous substitutions were found in , and genes across 14 mammals. By contrast, we identified recent positive selection in in primates. Additionally, the GA branch test discovered lineage-specific evolution for distinct EDC genes occurring in each of the nodes in the 14-mammal phylogenetic tree. Multiple instances of positive selection for , and were noted among the primate branch nodes. Branch-site likelihood ratio tests further revealed positive selection in specific sites in , and across 14 mammals. However, in addition to continuous evolution of , site-specific positive selection was also found in , and in primates and , and in great apes. Very recent human positive selection was identified in the L41 site that was present in Neanderthal. Together, our results identifying recent positive selection in distinct EDC genes reveal an underappreciated evolution of epidermal skin barrier function in primates and humans.

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