The Green Microalga Tetraselmis Suecica Reduces Oxidative Stress and Induces Repairing Mechanisms in Human Cells

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jan 25

PMID 28117410

Citations 44

Authors

Clementina Sansone

Christian Galasso

Ida Orefice

Genoveffa Nuzzo

Elvira Luongo

Adele Cutignano

Giovanna Romano

Christophe Brunet

Angelo Fontana

Francesco Esposito

Adrianna Ianora

Affiliations

Soon will be listed here.

Abstract

Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E (PGE) levels in cells damaged by HO and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm) indicating a potential cosmeceutical activity of this microalgal species.

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