Effect of Sodium Butyrate on Performance, Immune Status, Microarchitecture of Small Intestinal Mucosa and Lymphoid Organs in Broiler Chickens

Overview

Journal Asian-Australas J Anim Sci

Specialty Veterinary Medicine

Date 2017 Jan 24

PMID 28111438

Citations 32

Authors

Arbab Sikandar

Hafsa Zaneb

Muhammad Younus

Saima Masood

Asim Aslam

Farina Khattak

Saima Ashraf

Muhammad Shahbaz Yousaf

Habib Rehman

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine.

Methods: A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected.

Results: Cell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups.

Conclusion: In conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.

Citing Articles

In ovo sodium butyrate administration differentially impacts growth performance, intestinal barrier function, immune response, and gut microbiota characteristics in low and high hatch-weight broilers.

Akram M, Everaert N, Dunislawska A J Anim Sci Biotechnol. 2024; 15(1):165.

PMID: 39643908 PMC: 11624594. DOI: 10.1186/s40104-024-01122-4.

Dietary Tributyrin Improves Growth Performance, Meat Quality, Muscle Oxidative Status, and Gut Microbiota in Taihe Silky Fowls under Cyclic Heat Stress.

Chen C, Qu M, Li G, Wan G, Liu P, Omar S Animals (Basel). 2024; 14(20).

PMID: 39457971 PMC: 11504407. DOI: 10.3390/ani14203041.

Analyzing the morphology and avian β-defensins genes (AvβD) expression in the small intestine of Cobb500 broiler chicks fed with sodium butyrate.

Alsafy M, Abdellatif I, El-Gendy S, Abumandour M, Noreldin A, Bassuoni N BMC Vet Res. 2024; 20(1):434.

PMID: 39342153 PMC: 11438398. DOI: 10.1186/s12917-024-04253-y.

Effect of on the microarchitectural development of the immune system in -challenged broiler chickens.

Sikandar A, Zaneb H, Nasir A, Rehman A, Kashif M, Shah M Vet Med (Praha). 2024; 67(1):28-37.

PMID: 39169959 PMC: 11334965. DOI: 10.17221/231/2020-VETMED.

Sodium butyrate and rosemary herb improve growth performance, biochemical profile, immunity, and carcass traits in broiler chickens.

Shalaby M, Saifan H, Abo-El-Sooud K, Tony M, Yassin A Open Vet J. 2024; 14(5):1243-1250.

PMID: 38938426 PMC: 11199749. DOI: 10.5455/OVJ.2024.v14.i5.19.

References

Qaisrani S, van Krimpen M, Kwakkel R, Verstegen M, Hendriks W . Diet structure, butyric acid, and fermentable carbohydrates influence growth performance, gut morphology, and cecal fermentation characteristics in broilers. Poult Sci. 2015; 94(9):2152-64. PMC: 4988549. DOI: 10.3382/ps/pev003. View

El-Abasy M, Motobu M, Sameshima T, Koge K, Onodera T, Hirota Y . Adjuvant effects of sugar cane extracts (SCE) in chickens. J Vet Med Sci. 2003; 65(1):117-9. DOI: 10.1292/jvms.65.117. View

Park J, Kim M, Kang S, Jannasch A, Cooper B, Patterson J . Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol. 2014; 8(1):80-93. PMC: 4263689. DOI: 10.1038/mi.2014.44. View

Van Immerseel F, Fievez V, De Buck J, Pasmans F, Martel A, Haesebrouck F . Microencapsulated short-chain fatty acids in feed modify colonization and invasion early after infection with Salmonella enteritidis in young chickens. Poult Sci. 2004; 83(1):69-74. DOI: 10.1093/ps/83.1.69. View

Fang C, Sun H, Wu J, Niu H, Feng J . Effects of sodium butyrate on growth performance, haematological and immunological characteristics of weanling piglets. J Anim Physiol Anim Nutr (Berl). 2013; 98(4):680-5. DOI: 10.1111/jpn.12122. View

Zhang W, Jiang Y, Zhu Q, Gao F, Dai S, Chen J . Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens. Br Poult Sci. 2011; 52(3):292-301. DOI: 10.1080/00071668.2011.578121. View

Zhou Z, Packialakshmi B, Makkar S, Dridi S, Rath N . Effect of butyrate on immune response of a chicken macrophage cell line. Vet Immunol Immunopathol. 2014; 162(1-2):24-32. DOI: 10.1016/j.vetimm.2014.09.002. View

Madej J, Stefaniak T, Bednarczyk M . Effect of in ovo-delivered prebiotics and synbiotics on lymphoid-organs' morphology in chickens. Poult Sci. 2015; 94(6):1209-19. DOI: 10.3382/ps/pev076. View

Schrank C, Cook M, Hansen W . Immune response of mallard ducks treated with immunosuppressive agents: antibody response to erythrocytes and in vivo response to phytohemagglutinin-P. J Wildl Dis. 1990; 26(3):307-15. DOI: 10.7589/0090-3558-26.3.307. View

10.

Geng T, Guan X, Smith E . Screening for genes involved in antibody response to sheep red blood cells in the chicken, Gallus gallus. Poult Sci. 2015; 94(9):2099-107. DOI: 10.3382/ps/pev224. View

11.

King D . A comparison of the onset of protection induced by Newcastle disease virus strain B1 and a fowl poxvirus recombinant Newcastle disease vaccine to a viscerotropic velogenic Newcastle disease virus challenge. Avian Dis. 1999; 43(4):745-55. View

12.

Rieger J, Janczyk P, Hunigen H, Neumann K, Plendl J . Intraepithelial lymphocyte numbers and histomorphological parameters in the porcine gut after Enterococcus faecium NCIMB 10415 feeding in a Salmonella Typhimurium challenge. Vet Immunol Immunopathol. 2015; 164(1-2):40-50. DOI: 10.1016/j.vetimm.2014.12.013. View

13.

Chang P, Hao L, Offermanns S, Medzhitov R . The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2014; 111(6):2247-52. PMC: 3926023. DOI: 10.1073/pnas.1322269111. View

14.

Corrier D . Comparison of phytohemagglutinin-induced cutaneous hypersensitivity reactions in the interdigital skin of broiler and layer chicks. Avian Dis. 1990; 34(2):369-73. View

15.

Ashraf S, Zaneb H, Yousaf M, Ijaz A, Sohail M, Muti S . Effect of dietary supplementation of prebiotics and probiotics on intestinal microarchitecture in broilers reared under cyclic heat stress. J Anim Physiol Anim Nutr (Berl). 2013; 97 Suppl 1:68-73. DOI: 10.1111/jpn.12041. View

16.

Eshak M, Elmenawey M, Atta A, Gharib H, Shalaby B, Awaad M . The efficacy of Na-butyrate encapsulated in palm fat on performance of broilers infected with necrotic enteritis with gene expression analysis. Vet World. 2016; 9(5):450-7. PMC: 4893714. DOI: 10.14202/vetworld.2016.450-457. View

17.

Sunkara L, Achanta M, Schreiber N, Bommineni Y, Dai G, Jiang W . Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression. PLoS One. 2011; 6(11):e27225. PMC: 3208584. DOI: 10.1371/journal.pone.0027225. View