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Hepatocellular Carcinoma in Identical Twins in Chile: Case Report

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Specialty Oncology
Date 2017 Jan 21
PMID 28105079
Citations 1
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Abstract

Liver cancer is the second leading cause of cancer death worldwide, with hepatocellular carcinoma (HCC) being the most common type of primary malignant liver tumour, with a typically poor prognosis, growing incidence and a well-documented relationship with chronic inflammation factors of the liver tissue. Despite the fact that family medical history has been identified as a risk factor for the development of HCC, its significance in terms of etiopathogenesis and prognosis is not well documented. With a view to contributing to this discussion, we will report the clinical case of two identical twins with HCC, both diagnosed within a short period of time, by providing relevant clinical data, and relating this to other medical literature reports that could contribute to a deeper understanding of this illness.

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References
1.
Forner A, Llovet J, Bruix J . Hepatocellular carcinoma. Lancet. 2012; 379(9822):1245-55. DOI: 10.1016/S0140-6736(11)61347-0. View

2.
Demir G, Belentepe S, Ozguroglu M, Celik A, Sayhan N, Tekin S . Simultaneous presentation of hepatocellular carcinoma in identical twin brothers. Med Oncol. 2002; 19(2):113-6. DOI: 10.1385/MO:19:2:113. View

3.
Roos L, Spector T, Bell C . Using epigenomic studies in monozygotic twins to improve our understanding of cancer. Epigenomics. 2014; 6(3):299-309. DOI: 10.2217/epi.14.13. View

4.
Kaplan L, Cole S . FRATERNAL PRIMARY HEPATOCELLULAR CARCINOMA IN THREE MALE, ADULT SIBLINGS. Am J Med. 1965; 39:305-11. DOI: 10.1016/0002-9343(65)90056-2. View

5.
Hattersley A, McCarthy M . What makes a good genetic association study?. Lancet. 2005; 366(9493):1315-23. DOI: 10.1016/S0140-6736(05)67531-9. View