Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Jan 20

PMID 28103276

Citations 11

Authors

Parviz Ayazi

Abolfazl Mahyar

Mahdieh Yousef-Zanjani

Abbas Allami

Neda Esmailzadehha

Taraneh Beyhaghi

Affiliations

Soon will be listed here.

Abstract

Coughing in a child induced by upper respiratory tract infections (URTIs) can be a problem, both for the child and its parents. Current studies show a lack of proven efficacy for over-the counter (OTC) medications, but promising data support the use of honey for children. The aim of this study was to compare the effects of two kinds of Iranian honey with diphenhydramine (DPH) on nocturnal pediatric coughs and the sleep quality of children and their parents. This was a clinical trial (registered in IRCT; No.: 28.20.7932, 15 October 2013). The study consisted of 87 patients. All the parents completed a standard previously validated questionnaire. The children were randomly assigned to one of three treatment groups: Group 1, Honey type 1 (Kimia Company, Iran) (n = 42), Group 2, Honey type 2 (Shahde-Golha, Iran) (n = 25), and Group 3, DPH (n = 20). Each group received double doses of the respective treatments on two successive nights. A second survey was then administered via a telephone interview in which the parents were asked the same questions. The mean scores for all aspects of coughs were significantly decreased in each group before and after the treatment. All three treatments improved the cough and sleep scores. Honey type 1 was superior to DPH in improving all aspects of coughs, except the frequency, and Honey type 2 was more effective than DPH in improving all aspects of coughs, except the sleep quality of the child. There was no significant difference between Honey type 1 and 2 in any aspects of cough relief in the present study. The results suggest that honey may provide better cough relief than DPH in children and improve the sleep quality of children and their parents.

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References

Radovanovic D, Meier P, Guirguis M, Lorent J, Kupferschmidt H . Dose-dependent toxicity of diphenhydramine overdose. Hum Exp Toxicol. 2001; 19(9):489-95. DOI: 10.1191/096032700671040438. View

Dart R, Paul I, Bond G, Winston D, Manoguerra A, Palmer R . Pediatric fatalities associated with over the counter (nonprescription) cough and cold medications. Ann Emerg Med. 2008; 53(4):411-7. DOI: 10.1016/j.annemergmed.2008.09.015. View

Jones J, Dougherty J, Cannon L . Diphenhydramine-induced toxic psychosis. Am J Emerg Med. 1986; 4(4):369-71. DOI: 10.1016/0735-6757(86)90312-8. View

Shadkam M, Mozaffari-Khosravi H, Mozayan M . A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. J Altern Complement Med. 2010; 16(7):787-93. DOI: 10.1089/acm.2009.0311. View

Lusby P, Coombes A, Wilkinson J . Bactericidal activity of different honeys against pathogenic bacteria. Arch Med Res. 2005; 36(5):464-7. DOI: 10.1016/j.arcmed.2005.03.038. View

Bjornsdottir I, Einarson T, Gudmundsson L, Einarsdottir R . Efficacy of diphenhydramine against cough in humans: a review. Pharm World Sci. 2007; 29(6):577-83. DOI: 10.1007/s11096-007-9122-2. View

Tonks A, Cooper R, Jones K, Blair S, Parton J, Tonks A . Honey stimulates inflammatory cytokine production from monocytes. Cytokine. 2003; 21(5):242-7. DOI: 10.1016/s1043-4666(03)00092-9. View

Arroll B . Non-antibiotic treatments for upper-respiratory tract infections (common cold). Respir Med. 2005; 99(12):1477-84. DOI: 10.1016/j.rmed.2005.09.039. View

Cohen H, Rozen J, Kristal H, Laks Y, Berkovitch M, Uziel Y . Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study. Pediatrics. 2012; 130(3):465-71. DOI: 10.1542/peds.2011-3075. View

10.

de Nesnera A . Diphenhydramine dependence: a need for awareness. J Clin Psychiatry. 1996; 57(3):136-7. View

11.

Paul I . Therapeutic options for acute cough due to upper respiratory infections in children. Lung. 2011; 190(1):41-4. DOI: 10.1007/s00408-011-9319-y. View

12.

Nevas M, Hielm S, Lindstrom M, Horn H, Koivulehto K, Korkeala H . High prevalence of Clostridium botulinum types A and B in honey samples detected by polymerase chain reaction. Int J Food Microbiol. 2002; 72(1-2):45-52. DOI: 10.1016/s0168-1605(01)00615-8. View

13.

Paul I, Yoder K, Crowell K, Shaffer M, McMillan H, Carlson L . Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics. 2004; 114(1):e85-90. DOI: 10.1542/peds.114.1.e85. View

14.

Gheldof N, Wang X, Engeseth N . Buckwheat honey increases serum antioxidant capacity in humans. J Agric Food Chem. 2003; 51(5):1500-5. DOI: 10.1021/jf025897t. View

15.

Eccles R . Mechanisms of the placebo effect of sweet cough syrups. Respir Physiol Neurobiol. 2005; 152(3):340-8. DOI: 10.1016/j.resp.2005.10.004. View

16.

Landau L . Acute and chronic cough. Paediatr Respir Rev. 2006; 7 Suppl 1:S64-7. DOI: 10.1016/j.prrv.2006.04.172. View

17.

Rimsza M, Newberry S . Unexpected infant deaths associated with use of cough and cold medications. Pediatrics. 2008; 122(2):e318-22. DOI: 10.1542/peds.2007-3813. View

18.

Oduwole O, Meremikwu M, Oyo-Ita A, Udoh E . Honey for acute cough in children. Cochrane Database Syst Rev. 2014; (12):CD007094. DOI: 10.1002/14651858.CD007094.pub4. View

19.

Finkle W, Adams J, Greenland S, Melmon K . Increased risk of serious injury following an initial prescription for diphenhydramine. Ann Allergy Asthma Immunol. 2002; 89(3):244-50. DOI: 10.1016/S1081-1206(10)61950-3. View

20.

Warren M, Pont S, Barkin S, Callahan S, Caples T, Carroll K . The effect of honey on nocturnal cough and sleep quality for children and their parents. Arch Pediatr Adolesc Med. 2007; 161(12):1149-53. DOI: 10.1001/archpedi.161.12.1149. View