Protective Effect of Taraxasterol Against Rheumatoid Arthritis by the Modulation of Inflammatory Responses in Mice

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2017 Jan 20

PMID 28101182

Citations 8

Authors

Shu-Hua Jiang

Li-Feng Ping

Feng-Yan Sun

Xiao-Lei Wang

Zhi-Juan Sun

Affiliations

Soon will be listed here.

Abstract

Taraxasterol is an effective component of dandelion that has anti-inflammatory effects and . The present study was performed to explore whether taraxasterol exhibits a protective effect against rheumatoid arthritis through the modulation of inflammatory responses in mice. Eight-week-old CCR9-deficient mice were injected with a collagen II monoclonal antibody cocktail to create a rheumatoid arthritis model. In the experimental group, arthritic model mice were treated with 10 mg/kg taraxasterol once per day for 5 days. Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of the mice in the experimental group compared with those of the model group. Furthermore, treatment with taraxasterol significantly suppressed tumor necrosis factor-α, interleukin (IL)-1β, IL-6 and nuclear factor-κB protein expression levels compared with those in the rheumatoid arthritis model mice. Taraxasterol treatment also significantly reduced nitric oxide, prostaglandin E2 and cyclooxygenase-2 levels compared with those in the rheumatoid arthritis model group. These observations indicate that the protective effect of taraxasterol against rheumatoid arthritis is mediated via the modulation of inflammatory responses in mice.

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