Benzene Poisoning, Clinical and Blood Abnormalities in Two Brazilian Female Gas Station Attendants: Two Case Reports

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2017 Jan 20

PMID 28100263

Citations 6

Authors

Fabio Santiago

Simone Lima

Tayna Pinheiro

Rafaele Tavares Silvestre

Ubirani Barros Otero

Marianne Medeiros Tabalipa

Nadezda Kosyakova

Maria Helena Ornellas

Thomas Liehr

Gilda Alves

Affiliations

Soon will be listed here.

Abstract

Background: Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history.

Case Presentation: In both cases were identified complex chromosomal rearrangements (CCR) with fluorescence in situ hybridization, applied to whole chromosome paints by chromosomes 1, 2 and 4. The lower natural killer cell (NK) cells have also been observed in cases correspondents, especially the rare type of NK (NKbright) in their peripheral blood cells.

Conclusions: It is known that acquired chromosomal aberrations are positively correlated with cancer and reproductive risk. In concordance, lower NK cytotoxicity increases the risk for cancer, as well. Thus, this is the first study providing hints on a possible causative relation of lower NK cytotoxicity and increase rates of chromosomal rearrangements including CCRs.

Citing Articles

Recent Advances in Biomonitoring of Gas Station Workers: A Systematic Review.

Lima S, Santiago F, Silvestre R, Elexias S, Ornellas M, Carvalho M Asian Pac J Cancer Prev. 2024; 25(10):3439-3445.

PMID: 39471009 PMC: 11711367. DOI: 10.31557/APJCP.2024.25.10.3439.

Toxicological Effects of Technical Xylene Mixtures on the Female Reproductive System: A Systematic Review.

Suaidi N, Alshawsh M, Hoe S, Mokhtar M, Md Zin S Toxics. 2022; 10(5).

PMID: 35622648 PMC: 9144477. DOI: 10.3390/toxics10050235.

Photocatalytic Oxidation of PLA/TiO-Composite Films for Indoor Air Purification.

Chanklom P, Kreetachat T, Chotigawin R, Suwannahong K ACS Omega. 2021; 6(16):10629-10636.

PMID: 34056216 PMC: 8153744. DOI: 10.1021/acsomega.0c06194.

The association of three DNA repair genes polymorphisms on the frequency of chromosomal alterations detected by fluorescence in situ hybridization.

Santiago F, Silvestre R, Otero U, Tabalipa M, Ribeiro-Carvalho M, Scherrer L Int Arch Occup Environ Health. 2021; 94(7):1567-1577.

PMID: 33778923 PMC: 8384795. DOI: 10.1007/s00420-021-01652-8.

Benzene-associated immunosuppression and chronic inflammation in humans: a systematic review.

Guo H, Ahn S, Zhang L Occup Environ Med. 2020; .

PMID: 32938756 PMC: 7960562. DOI: 10.1136/oemed-2020-106517.

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