Antispasmodic, Bronchodilator, Vasorelaxant and Cardiosuppressant Effects of Buxus Papillosa

Overview

Journal BMC Complement Altern Med

Publisher Biomed Central

Specialty Rehabilitation Medicine

Date 2017 Jan 20

PMID 28100216

Citations 2

Authors

Arif-Ullah Khan

Shamsher Ali

Anwarul-Hassan Gilani

Manzoor Ahmed

Muhammad Iqbal Choudhary

Affiliations

Soon will be listed here.

Abstract

Background: The present research was carried out to investigate pharmacological properties of Buxus papillosa C.K. Schneid. (Buxaceae).

Methods: Buxus papillosa extracts of leaves (BpL), stem (BpS), roots (BpR) and BpL fractions: hexane (BpL-H), aqueous (BpL-A) also plant constituent, cyclomicrobuxine effect were studied in jejunum, atria, aorta and tracheal preparations from rabbit and guine-peg.

Results: Ca antagonistic effect of BpS, BpR, BpL-H, BpL-A and cyclomicrobuxine were conclusively suggested, when spontaneous contractions of rabbit jejunal preparation was relaxed along with subsequent relaxation of potassium chloride (80 mM) induced contractions. Ca antagonistic effect was further confirmed, when a prominent right shift like that of verapamil was observed in Ca concentration-response curves, drawn in a tissue pretreated with BpL (0.3-1.0 mg/mL). In rabbit tracheal tissues BpL, BpS, BpR, BpL-H and BpL-A produced a prominent relaxation in contractions induced by potassium chloride (80 mM) and carbachol (1 μm). When tested in rabbit aortic rings, BpL, BpS, BpR, BpL-H and BpL-A showed concentration-dependent (0.1-3.0 mg/mL) vasorelaxant effect against phenylephrine (1 μM) and high K-induced contractions. In isolated guinea-pig right atria, BpL, BpS, BpR, BpL-H and BpL-A suppressed atrial force of spontaneous contractions, with BpL-A being most potent.

Conclusions: Our results reveal that Buxus papillosa possesses gut, airways and cardiovascular inhibitory actions.

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