Skeletal Muscle Aging: Influence of Oxidative Stress and Physical Exercise

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Jan 19

PMID 28099900

Citations 124

Authors

Mariana Janini Gomes

Paula Felippe Martinez

Luana Urbano Pagan

Ricardo Luiz Damatto

Marcelo Diacardia Mariano Cezar

Aline Regina Ruiz Lima

Katashi Okoshi

Marina Politi Okoshi

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes. An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities. Currently, despite the discovery of new targets and development of new drugs, nonpharmacological therapies such as physical exercise and nutritional support are considered the basis for prevention and treatment of age-associated muscle abnormalities. There has been an increase in information on signaling pathways beneficially modulated by exercise; nonetheless, studies are needed to establish the best type, intensity, and frequency of exercise to prevent or treat age-induced skeletal muscle alterations.

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References

Radak Z, Pucsok J, Mecseki S, Csont T, Ferdinandy P . Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle. Free Radic Biol Med. 1999; 26(7-8):1059-63. DOI: 10.1016/s0891-5849(98)00309-8. View

Visser M, Deeg D, Lips P, Harris T, Bouter L . Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women. J Am Geriatr Soc. 2000; 48(4):381-6. DOI: 10.1111/j.1532-5415.2000.tb04694.x. View

Cadenas E, Davies K . Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000; 29(3-4):222-30. DOI: 10.1016/s0891-5849(00)00317-8. View

Greiwe J, Cheng B, Rubin D, Yarasheski K, Semenkovich C . Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J. 2001; 15(2):475-82. DOI: 10.1096/fj.00-0274com. View

McArdle A, Jackson M . Exercise, oxidative stress and ageing. J Anat. 2001; 197 Pt 4:539-41. PMC: 1468168. DOI: 10.1046/j.1469-7580.2000.19740539.x. View

Campbell W, Trappe T, Wolfe R, Evans W . The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci. 2001; 56(6):M373-80. DOI: 10.1093/gerona/56.6.m373. View

Bodine S, Stitt T, Gonzalez M, Kline W, Stover G, Bauerlein R . Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol. 2001; 3(11):1014-9. DOI: 10.1038/ncb1101-1014. View

Janssen I, Heymsfield S, Ross R . Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002; 50(5):889-96. DOI: 10.1046/j.1532-5415.2002.50216.x. View

Radak Z, Apor P, Pucsok J, Berkes I, Ogonovszky H, Pavlik G . Marathon running alters the DNA base excision repair in human skeletal muscle. Life Sci. 2003; 72(14):1627-33. DOI: 10.1016/s0024-3205(02)02476-1. View

10.

Welle S, Brooks A, Delehanty J, Needler N, Thornton C . Gene expression profile of aging in human muscle. Physiol Genomics. 2003; 14(2):149-59. DOI: 10.1152/physiolgenomics.00049.2003. View

11.

Morley J . Hormones and the aging process. J Am Geriatr Soc. 2003; 51(7 Suppl):S333-7. DOI: 10.1046/j.1365-2389.2003.51344.x. View

12.

Harman D . Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3):298-300. DOI: 10.1093/geronj/11.3.298. View

13.

Bhasin S, Taylor W, Singh R, Artaza J, Sinha-Hikim I, Jasuja R . The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci. 2003; 58(12):M1103-10. DOI: 10.1093/gerona/58.12.m1103. View

14.

Fulle S, Protasi F, Di Tano G, Pietrangelo T, Beltramin A, Boncompagni S . The contribution of reactive oxygen species to sarcopenia and muscle ageing. Exp Gerontol. 2004; 39(1):17-24. DOI: 10.1016/j.exger.2003.09.012. View

15.

Sacheck J, Ohtsuka A, McLary S, Goldberg A . IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab. 2004; 287(4):E591-601. DOI: 10.1152/ajpendo.00073.2004. View

16.

Fatouros I, Jamurtas A, Villiotou V, Pouliopoulou S, Fotinakis P, Taxildaris K . Oxidative stress responses in older men during endurance training and detraining. Med Sci Sports Exerc. 2004; 36(12):2065-72. DOI: 10.1249/01.mss.0000147632.17450.ff. View

17.

Phillips T, Leeuwenburgh C . Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB J. 2005; 19(6):668-70. DOI: 10.1096/fj.04-2870fje. View

18.

Kuh D, Bassey E, Butterworth S, Hardy R, Wadsworth M . Grip strength, postural control, and functional leg power in a representative cohort of British men and women: associations with physical activity, health status, and socioeconomic conditions. J Gerontol A Biol Sci Med Sci. 2005; 60(2):224-31. DOI: 10.1093/gerona/60.2.224. View

19.

Radak Z, Young Chung H, Goto S . Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology. 2005; 6(1):71-5. DOI: 10.1007/s10522-004-7386-7. View

20.

Guillet C, Boirie Y . Insulin resistance: a contributing factor to age-related muscle mass loss?. Diabetes Metab. 2006; 31 Spec No 2:5S20-5S26. DOI: 10.1016/s1262-3636(05)73648-x. View