DHEA and Frontal Fibrosing Alopecia: Molecular and Physiopathological Mechanisms

Overview

Journal An Bras Dermatol

Specialty Dermatology

Date 2017 Jan 19

PMID 28099600

Citations 7

Authors

Neide Kalil Gaspar

Affiliations

Soon will be listed here.

Abstract

The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a negative regulator of fibrotic events induced by TGFβ1. Dehydroepiandrosterone (DHEA) is an immunomodulatory hormone essential for PPAR functions, and is reduced in some processes characterized by fibrosis. Although scarring alopecia characteristically develops in the female biological period in which occurs decreased production of DHEA, there are no data in the literature relating its reduction to fibrogenic process of this condition. This article aims to review the fibrogenic activity of TGFβ1, its control by PPAR and its relation with DHEA in the frontal fibrosing alopecia.

Citing Articles

Frontal Fibrosing Alopecia: An Update.

Messenger A, Asfour L, Harries M Am J Clin Dermatol. 2024; 26(2):155-174.

PMID: 39699852 DOI: 10.1007/s40257-024-00912-w.

Clinical and demographic characteristics of frontal fibrosing alopecia in a dermatology referral center in Bogota, Colombia: a descriptive cross-sectional study.

Gallego-Vidales L, Palacios-Ariza M, Macias-Arias P, Morales-Cardona C Int J Womens Dermatol. 2024; 10(4):e188.

PMID: 39545223 PMC: 11563004. DOI: 10.1097/JW9.0000000000000188.

Frontal Fibrosing Alopecia and Reproductive Health: Assessing the Role of Sex Hormones in Disease Development.

Roman A, Petca R, Dumitrascu M, Petca A, Ionescu Miron A, Sandru F J Pers Med. 2024; 14(1).

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Frontal fibrosing alopecia: A review of disease pathogenesis.

Miao Y, Jing J, Du X, Mao M, Yang X, Lv Z Front Med (Lausanne). 2022; 9:911944.

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The Utilization of Dehydroepiandrosterone as a Sexual Hormone Precursor in Premenopausal and Postmenopausal Women: An Overview.

Tang J, Chen L, Chen K Pharmaceuticals (Basel). 2022; 15(1).

PMID: 35056103 PMC: 8781653. DOI: 10.3390/ph15010046.

References

Patel M, Katyare S . Dehydroepiandrosterone (DHEA) treatment stimulates oxidative energy metabolism in the cerebral mitochondria from developing rats. Int J Dev Neurosci. 2006; 24(5):327-34. DOI: 10.1016/j.ijdevneu.2006.04.005. View

Chen X, Liu X, Wang Q, Zhang M, Guo M, Liu F . Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-κB/TGF-β1/TRIF/TRAF6 pathway. Exp Cell Res. 2014; 330(1):43-55. DOI: 10.1016/j.yexcr.2014.08.021. View

Schmuth M, Haqq C, Cairns W, Holder J, Dorsam S, Chang S . Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol. 2004; 122(4):971-83. DOI: 10.1111/j.0022-202X.2004.22412.x. View

Ninomiya I, Yamazaki K, Oyama K, Hayashi H, Tajima H, Kitagawa H . Pioglitazone inhibits the proliferation and metastasis of human pancreatic cancer cells. Oncol Lett. 2014; 8(6):2709-2714. PMC: 4214501. DOI: 10.3892/ol.2014.2553. View

Hao G, Niu X, Gao D, Wei J, Wang N . Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts. Br J Pharmacol. 2008; 153(7):1409-19. PMC: 2437920. DOI: 10.1038/bjp.2008.21. View

Ham S, Kang E, Lee H, Hwang J, Yoo T, Paek K . PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling. J Invest Dermatol. 2013; 133(11):2593-2600. DOI: 10.1038/jid.2013.202. View

Zhang J, Fang N, Gao P, Wu L, Han W, Guo S . Peroxisome proliferator-activated receptor-gamma agonists attenuate angiotensin II-induced collagen type I expression in adventitial fibroblasts. Clin Exp Pharmacol Physiol. 2007; 35(1):72-7. DOI: 10.1111/j.1440-1681.2007.04748.x. View

Mirmirani P, Karnik P . Lichen planopilaris treated with a peroxisome proliferator-activated receptor gamma agonist. Arch Dermatol. 2009; 145(12):1363-6. PMC: 2937154. DOI: 10.1001/archdermatol.2009.283. View

Georgala S, Katoulis A, Befon A, Danopoulou I, Georgala C . Treatment of postmenopausal frontal fibrosing alopecia with oral dutasteride. J Am Acad Dermatol. 2009; 61(1):157-8. DOI: 10.1016/j.jaad.2008.12.026. View

10.

Jouanique C, Reygagne P . [Frontal fibrosing alopecia]. Ann Dermatol Venereol. 2014; 141(4):272-8. DOI: 10.1016/j.annder.2014.01.020. View

11.

Ghosh A, Bhattacharyya S, Wei J, Kim S, Barak Y, Mori Y . Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator. FASEB J. 2009; 23(9):2968-77. PMC: 2735362. DOI: 10.1096/fj.08-128736. View

12.

MacDonald A, Clark C, Holmes S . Frontal fibrosing alopecia: a review of 60 cases. J Am Acad Dermatol. 2012; 67(5):955-61. DOI: 10.1016/j.jaad.2011.12.038. View

13.

Poczatkova H, Bogdanova K, Uherkova L, Cervenkova K, Riegrova D, Rypka M . Dehydroepiandrosterone effects on the mRNA levels of peroxisome proliferator-activated receptors and their coactivators in human hepatoma HepG2 cells. Gen Physiol Biophys. 2008; 26(4):268-74. View

14.

Feige J, Gelman L, Michalik L, Desvergne B, Wahli W . From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res. 2006; 45(2):120-59. DOI: 10.1016/j.plipres.2005.12.002. View

15.

Bamberg E, Aichinger A, Mitteregger G . In vitro metabolism of dehydroepiandrosterone and testosterone by canine hair follicle cells. Vet Dermatol. 2004; 15(1):19-24. DOI: 10.1111/j.1365-3164.2004.00366.x. View

16.

Zafiriou S, Stanners S, Saad S, Polhill T, Poronnik P, Pollock C . Pioglitazone inhibits cell growth and reduces matrix production in human kidney fibroblasts. J Am Soc Nephrol. 2005; 16(3):638-45. DOI: 10.1681/ASN.2004040278. View

17.

Baibergenova A, Donovan J . Lichen planopilaris: update on pathogenesis and treatment. Skinmed. 2013; 11(3):161-5. View

18.

Poblet E, Jimenez F, Pascual A, Pique E . Frontal fibrosing alopecia versus lichen planopilaris: a clinicopathological study. Int J Dermatol. 2006; 45(4):375-80. DOI: 10.1111/j.1365-4632.2006.02507.x. View

19.

Shapiro R, Shapiro P . Hairline design and frontal hairline restoration. Facial Plast Surg Clin North Am. 2013; 21(3):351-62. DOI: 10.1016/j.fsc.2013.06.001. View

20.

Burgess H, Daugherty L, Thatcher T, Lakatos H, Ray D, Redonnet M . PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005; 288(6):L1146-53. DOI: 10.1152/ajplung.00383.2004. View