Mitochondria Initiate and Regulate Sarcopenia

Overview

Journal Exerc Sport Sci Rev

Specialty Orthopedics

Date 2017 Jan 19

PMID 28098577

Citations 74

Authors

Stephen E Alway

Junaith S Mohamed

Matthew J Myers

Affiliations

Soon will be listed here.

Abstract

We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.

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