Factors Associated with Echinococcosis-Induced Perioperative Anaphylactic Shock

Overview

Journal Korean J Parasitol

Specialty Parasitology

Date 2017 Jan 19

PMID 28095662

Citations 7

Authors

Jianrong Ye

Qin Zhang

Yan Xuan

Siyu Chen

Long Ma

Yongqiang Zhang

Hong Zheng

Affiliations

Soon will be listed here.

Abstract

This retrospective case-control study explored the factors associated with anaphylactic shock during surgery for cystic echinococcosis (CE) at the First Affiliated Hospital of Xinjiang Medical University between October 2008 and September 2013. Patients who suffered from anaphylactic shock (n=16) were age-matched 3:1 to patients who did not (n=43). Multivariate analysis suggested that IL-4 levels (odds ratio=1.096; 95% confidence interval=1.015-1.185; =0.02) and cyst size (odds ratio=3.028, 95% confidence interval=1.259-7.283, =0.013) were independently associated with CE-induced perioperative anaphylactic shock. Using the receiver operating characteristic (ROC) curves and a cut-off value of 415.7 ng/ml, IL-4 showed an area under the ROC (AUC) of 0.926, sensitivity of 75.0%, and specificity of 97.7%. Using a cut-off value of 7.8 cm, cyst size showed an AUC of 0.828, sensitivity of 81.3%, and specificity of 76.7%. In conclusion, results suggest that levels of IL-4 and cyst size were independently associated with echinococcosis-induced perioperative anaphylactic shock. These results could help identifying patients with echinococcosis at risk of anaphylactic shock in whom appropriate prophylaxis could be undertaken.

Citing Articles

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The regulatory role of differential microRNA expressions on cellular inflammatory factors IL-6 and IL-10 in Echinococcus granulosus-induced anaphylaxis.

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