Iron Overload and Altered Iron Metabolism in Ovarian Cancer

Overview

Journal Biol Chem

Specialty Biochemistry

Date 2017 Jan 18

PMID 28095368

Citations 26

Authors

Stephanie Rockfield

Joseph Raffel

Radhe Mehta

Nabila Rehman

Meera Nanjundan

Affiliations

Soon will be listed here.

Abstract

Iron is an essential element required for many processes within the cell. Dysregulation in iron homeostasis due to iron overload is detrimental. This nutrient is postulated to contribute to the initiation of cancer; however, the mechanisms by which this occurs remain unclear. Defining how iron promotes the development of ovarian cancers from precursor lesions is essential for developing novel therapeutic strategies. In this review, we discuss (1) how iron overload conditions may initiate ovarian cancer development, (2) dysregulated iron metabolism in cancers, (3) the interplay between bacteria, iron, and cancer, and (4) chemotherapeutic strategies targeting iron metabolism in cancer patients.

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