Paracrine Cross-talk Between Skeletal Muscle and Macrophages in Exercise by PGC-1α-controlled BNP

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jan 17

PMID 28091624

Citations 17

Authors

Regula Furrer

Petra S Eisele

Alexander Schmidt

Markus Beer

Christoph Handschin

Affiliations

Soon will be listed here.

Abstract

Activation of resident and infiltrating immune cells is a central event in training adaptation and other contexts of skeletal muscle repair and regeneration. A precise orchestration of inflammatory events in muscle fibers and immune cells is required after recurrent contraction-relaxation cycles. However, the mechanistic aspects of this important regulation remain largely unknown. We now demonstrate that besides a dominant role in controlling cellular metabolism, the peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) also has a profound effect on cytokine expression in muscle tissue. Muscle PGC-1α expression results in activation of tissue-resident macrophages, at least in part mediated by PGC-1α-dependent B-type natriuretic peptide (BNP) production and secretion. Positive effects of exercise in metabolic diseases and other pathologies associated with chronic inflammation could accordingly involve the PGC-1α-BNP axis and thereby provide novel targets for therapeutic approaches.

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